ArticleFEBS letters2009
Translation termination in pyrrolysine-utilizing archaea.
Article in FEBS letters, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Pyrrolysine supply and demand shapes the translational landscape inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Methanogenic archaea encoding Pyrrolysine maintain ambiguous amber codon usage.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- High throughput screening of eukaryotic release factor 1 variants to enhance noncanonical amino acid incorporation.bioRxiv : the preprint server for biology · 2025Article
- Identification of key steps in the evolution of anaerobic methanotrophy inScience advances · 2025Article
- Reaching New Heights in Genetic Code Manipulation with High Throughput Screening.Chemical reviews · 2024Review
- Article
- Unconventional genetic code systems in archaea.Frontiers in microbiology · 2022Review
- RNA helicase DDX19 stabilizes ribosomal elongation and termination complexes.Nucleic acids research · 2017Article
- PABP enhances release factor recruitment and stop codon recognition during translation termination.Nucleic acids research · 2016Article
- Genetic code flexibility in microorganisms: novel mechanisms and impact on physiology.Nature reviews. Microbiology · 2015Review
- Stabilization of eukaryotic ribosomal termination complexes by deacylated tRNA.Nucleic acids research · 2015Article
- Two-step model of stop codon recognition by eukaryotic release factor eRF1.Nucleic acids research · 2013Article
- Carbon source-dependent expansion of the genetic code in bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Translational recoding in archaea.Extremophiles : life under extreme conditions · 2012Review
- Functional context, biosynthesis, and genetic encoding of pyrrolysine.Current opinion in microbiology · 2011Review
- A single amino acid change of translation termination factor eRF1 switches between bipotent and omnipotent stop-codon specificity.Nucleic acids research · 2011Article
- Codon reassignment in the Escherichia coli genetic code.Nucleic acids research · 2010Article
- Fidelity in archaeal information processing.Archaea (Vancouver, B.C.) · 2010Review
- Selenocysteine, pyrrolysine, and the unique energy metabolism of methanogenic archaea.Archaea (Vancouver, B.C.) · 2010Review
- NMR solution structure and function of the C-terminal domain of eukaryotic class 1 polypeptide chain release factor.The FEBS journal · 2010Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
Although some data link archaeal and eukaryotic translation, the overall mechanism of protein synthesis in archaea remains largely obscure. Both archaeal (aRF1) and eukaryotic (eRF1) single release factors recognize all three stop codons. The archaeal genus Methanosarcinaceae contains two aRF1 homologs, and also uses the UAG stop to encode the 22nd amino acid, pyrrolysine. Here we provide an analysis of the last stage of archaeal translation in pyrrolysine-utilizing species. We demonstrated that only one of two Methanosarcina barkeri aRF1 homologs possesses activity and recognizes all three stop codons. The second aRF1 homolog may have another unknown function. The mechanism of pyrrolysine incorporation in the Methanosarcinaceae is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.