ArticleExperimental cell research2010
Promigratory and procontractile growth factor environments differentially regulate cell morphogenesis.
Article in Experimental cell research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Critical role of lipid membranes in polarization and migration of cells: a biophysical view.Biophysical reviews · 2021Review
- Physical constraints on accuracy and persistence during breast cancer cell chemotaxis.PLoS computational biology · 2019Article
- Effects of dynamic matrix remodelling onJournal of the Royal Society, Interface · 2017Article
- Involvement of PI3K and MMP1 in PDGF-induced Migration of Human Adipose-derived Stem Cells.Development & reproduction · 2017Article
- Regulation of Airway Inflammation by G-protein Regulatory Motif Peptides of AGS3 protein.Scientific reports · 2016Article
- Extracellular Matrix Rigidity-dependent Sphingosine-1-phosphate Secretion Regulates Metastatic Cancer Cell Invasion and Adhesion.Scientific reports · 2016Article
- PDGF‑stimulated dispersal of cell clusters and disruption of fibronectin matrix on three-dimensional collagen matrices requires matrix metalloproteinase-2.Molecular biology of the cell · 2015Article
- The Role of Thrombin and Cell Contractility in Regulating Clustering and Collective Migration of Corneal Fibroblasts in Different ECM Environments.Investigative ophthalmology & visual science · 2015Article
- Fibroblast morphogenesis on 3D collagen matrices: the balance between cell clustering and cell migration.Experimental cell research · 2013Review
- Fibroblast cluster formation on 3D collagen matrices requires cell contraction dependent fibronectin matrix organization.Experimental cell research · 2013Article
- Individual versus collective fibroblast spreading and migration: regulation by matrix composition in 3D culture.Experimental eye research · 2012Article
- Effects of freezing-induced cell-fluid-matrix interactions on the cells and extracellular matrix of engineered tissues.Biomaterials · 2011Article
- The differential regulation of cell motile activity through matrix stiffness and porosity in three dimensional collagen matrices.Biomaterials · 2010Article
- Physico-mechanical aspects of extracellular matrix influences on tumorigenic behaviors.Seminars in cancer biology · 2010Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Three-dimensional (3D) cell-matrix cultures provide a useful model to analyze and dissect the structural, functional, and mechanical aspects of cell-matrix interactions and motile behavior important for cell and tissue morphogenesis. In the current studies we tested the effects of serum and physiological growth factors on the morphogenetic behavior of human fibroblasts cultured on the surfaces of 3D collagen matrices. Fibroblasts in medium containing serum contracted into clusters, whereas cells in medium containing platelet-derived growth factor (PDGF) were observed to migrate as individuals. The clustering activity of serum appeared to depend on lysophosphatidic acid, required cell contraction based on inhibition by blocking Rho kinase or myosin II, and was reversed upon switching to PDGF. Oncogenic Ras transformed human fibroblasts did not exhibit serum-stimulated cell clustering. Our findings emphasize the importance of cell-specific promigratory and procontractile growth factor environments in the differential regulation of cell motile function and cell morphogenesis.
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