ReviewPacing and clinical electrophysiology : PACE2010
The Contribution of HCN4 to normal sinus node function in humans and animal models.
Review in Pacing and clinical electrophysiology : PACE, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- Paradigm shift: new concepts for HCN4 function in cardiac pacemaking.Pflugers Archiv : European journal of physiology · 2022Review
- Conserved Role of the Large Conductance Calcium-Activated Potassium Channel, KCirculation. Genomic and precision medicine · 2021Article
- Atrial and Sinoatrial Node Development in the Zebrafish Heart.Journal of cardiovascular development and disease · 2021Review
- Exercise and cardiac health: physiological and molecular insights.Nature metabolism · 2020Review
- Effects of Yiqi Tongyang on HCN4 Protein Phosphorylation in Damaged Rabbit Sinoatrial Node Cells.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- Protective effects of kaempferol against cardiac sinus node dysfunction via CaMKII deoxidization.Anatomy & cell biology · 2015Article
- Pacemaker activity of the human sinoatrial node: an update on the effects of mutations in HCN4 on the hyperpolarization-activated current.International journal of molecular sciences · 2015Review
- The effect of hyperpolarization-activated cyclic nucleotide-gated ion channel inhibitors on the vagal control of guinea pig airway smooth muscle tone.British journal of pharmacology · 2014Article
- HCN channels and heart rate.Molecules (Basel, Switzerland) · 2012Review
- Propofol and arrhythmias: two sides of the coin.Acta pharmacologica Sinica · 2011Review
- Overview of Basic Mechanisms of Cardiac Arrhythmia.Cardiac electrophysiology clinics · 2011Article
- Structural basis for the cAMP-dependent gating in the human HCN4 channel.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Although sinus node bradycardia is a very common clinical condition, the cellular mechanisms contributing to abnormal sinus node function are not clearly delineated. In recent publications, mutations in the hyperpolarization-activated, cyclic nucleotide-gated (HCN) 4 channels have been associated with sinus bradycardia. These channels are thought to be crucial in generating the spontaneous sinus node action potential, in accelerating the heart rate during sympathetic drive, and decelerating heart rate during vagal stimulation. Humans carrying HCN4 mutations indeed display significant bradycardia. Recent studies generating HCN4 knock out mice suggested that although HCN4 is crucial in early development, other mechanisms may also play a role in the accelerated heat rate achieved during sympathetic drive. In this review, we focus on genotype-phenotype correlation of these mutations and discuss the relative contribution of various ion channels to sinus node function. We also discuss the importance of HCN in treating clinical conditions such as brady- and tachycardia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.