ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2009
Cloning and characterization of voltage-gated calcium channel alpha1 subunits in Xenopus laevis during development.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Structural Insights into L-Type Voltage-Gated CaBiochemistry · 2026Article
- L-Type Voltage-Gated CaBiochemistry · 2025Article
- Calmodulin promotes a CaFEBS letters · 2022Article
- L-Type CaBiomolecules · 2021Review
- Functional assessment of the "two-hit" model for neurodevelopmental defects in Drosophila and X. laevis.PLoS genetics · 2021Article
- Altered Cav1.2 function in the Timothy syndrome mouse model produces ascending serotonergic abnormalities.The European journal of neuroscience · 2017Article
- Genetic variation in total number and locations of GnRH neurons identified using in situ hybridization in a wild-source population.Journal of experimental zoology. Part A, Ecological genetics and physiology · 2016Article
- T-type Calcium Channel Regulation of Neural Tube Closure and EphrinA/EPHA Expression.Cell reports · 2015Article
- The role of voltage-gated calcium channels in neurotransmitter phenotype specification: Coexpression and functional analysis in Xenopus laevis.The Journal of comparative neurology · 2014Article
- Exploiting the extraordinary genetic polymorphism of ciona for developmental genetics with whole genome sequencing.Genetics · 2014Article
- Modeling human neurodevelopmental disorders in the Xenopus tadpole: from mechanisms to therapeutic targets.Disease models & mechanisms · 2013Review
- Dissection, culture, and analysis of Xenopus laevis embryonic retinal tissue.Journal of visualized experiments : JoVE · 2012Article
- Theranostic effect of serial manganese-enhanced magnetic resonance imaging of human embryonic stem cell derived teratoma.Magnetic resonance in medicine · 2012Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Voltage-gated calcium channels play a critical role in regulating the Ca2+ activity that mediates many aspects of neural development, including neural induction, neurotransmitter phenotype specification, and neurite outgrowth. Using Xenopus laevis embryos, we describe the spatial and temporal expression patterns during development of the 10 pore-forming alpha1 subunits that define the channels' kinetic properties. In situ hybridization indicates that CaV1.2, CaV2.1, CaV2.2, and CaV3.2 are expressed during neurula stages throughout the neural tube. These, along with CaV1.3 and CaV2.3, beginning at early tail bud stages, and CaV3.1 at late tail bud stages, are detected in complex patterns within the brain and spinal cord through swimming tadpole stages. Additional expression of various alpha1 subunits was observed in the cranial ganglia, retina, olfactory epithelium, pineal gland, and heart. The unique expression patterns for the different alpha1 subunits suggests they are under precise spatial and temporal regulation and are serving specific functions during embryonic development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.