ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2009
Expression of the oscillating gene her1 is directly regulated by Hairy/Enhancer of Split, T-box, and Suppressor of Hairless proteins in the zebrafish segmentation clock.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- Importance of ultradian oscillations in neurogenesis during development and its implications for spinal cord regeneration.Frontiers in cell and developmental biology · 2025Review
- Article
- Cell coupling compensates for changes in single-cell Her6 dynamics and provides phenotypic robustness.Development (Cambridge, England) · 2024Article
- Ripply suppresses Tbx6 to induce dynamic-to-static conversion in somite segmentation.Nature communications · 2023Article
- Species-specific roles of the Notch ligands, receptors, and targets orchestrating the signaling landscape of the segmentation clock.Frontiers in cell and developmental biology · 2023Review
- Keeping development on time: Insights into post-transcriptional mechanisms driving oscillatory gene expression during vertebrate segmentation.Wiley interdisciplinary reviews. RNA · 2023Review
- Time and space in segmentation.Interface focus · 2021Article
- TBX2 overexpression promotes proliferation and invasion through epithelial-mesenchymal transition and ERK signaling pathway.Experimental and therapeutic medicine · 2019Article
- Spine Patterning Is Guided by Segmentation of the Notochord Sheath.Cell reports · 2018Article
- Dynamics of the slowing segmentation clock reveal alternating two-segment periodicity.Development (Cambridge, England) · 2015Article
- Tbx6, Mesp-b and Ripply1 regulate the onset of skeletal myogenesis in zebrafish.Development (Cambridge, England) · 2015Article
- Spatial gradients of protein-level time delays set the pace of the traveling segmentation clock waves.Development (Cambridge, England) · 2014Article
- Article
- Nonlinearity arising from noncooperative transcription factor binding enhances negative feedback and promotes genetic oscillations.Papers in physics · 2014Article
- Cell-fibronectin interactions propel vertebrate trunk elongation via tissue mechanics.Current biology : CB · 2013Article
- Single-cell-resolution imaging of the impact of Notch signaling and mitosis on segmentation clock dynamics.Developmental cell · 2012Article
- A cis-regulatory module upstream of deltaC regulated by Ntla and Tbx16 drives expression in the tailbud, presomitic mesoderm and somites.Developmental biology · 2012Article
- Fss/Tbx6 is required for central dermomyotome cell fate in zebrafish.Biology open · 2012Article
- The Her7 node modulates the network topology of the zebrafish segmentation clock via sequestration of the Hes6 hub.Development (Cambridge, England) · 2012Article
- Ancestral and conserved cis-regulatory architectures in developmental control genes.Developmental biology · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Somites are segmental units of the mesoderm in vertebrate embryos that give rise to the axial skeleton, muscle, and dermis. Somitogenesis occurs in a periodic manner and is governed by a segmentation clock that causes cells to undergo repeated oscillations of gene expression. Here, we present a detailed analysis of cis-regulatory elements that control oscillating expression of the zebrafish her1 gene in the anterior presomitic mesoderm. We identify binding sites for Her proteins and demonstrate that they are necessary for transcriptional repression. This result confirms that direct negative autoregulation of her gene expression constitutes part of the oscillator mechanism. We also characterize binding sites for fused somites/Tbx24 and Suppressor of Hairless proteins and show that they are required for activation of her1 expression. These data provide the foundation for a precise description of the regulatory grammar that defines oscillating gene expression in the zebrafish segmentation clock.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.