ArticleDiabetes/metabolism research and reviews2009
Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group.
Article in Diabetes/metabolism research and reviews, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Pathomechanisms of Diabetic Kidney Disease.Journal of clinical medicine · 2023Review
- The Play of Genes and Non-genetic Factors on Type 2 Diabetes.Frontiers in public health · 2019Review
- Undiagnosed Kidney Injury in Uninsured and Underinsured Diabetic African American Men and Putative Role of Meprin Metalloproteases in Diabetic Nephropathy.International journal of nephrology · 2018Article
- Genetics of Type 2 Diabetes in African Americans.Current diabetes reports · 2015Review
- Association of adiponectin gene polymorphism with adiponectin levels and risk for insulin resistance syndrome.International journal of preventive medicine · 2015Article
- A genomewide linkage scan of cocaine dependence and major depressive episode in two populations.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
- Susceptible mice: identifying a diabetic nephropathy disease locus using a murine model.Kidney international · 2010Article
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Authors and funding
34 authors at 16 institutions in 2 countries.
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Abstract
backgroundPrevious studies have shown that in addition to environmental influences, type 2 diabetes mellitus (T2DM) has a strong genetic component. The goal of the current study is to identify regions of linkage for T2DM in ethnically diverse populations.
methodsPhenotypic and genotypic data were obtained from African American (AA; total number of individuals [N] = 1004), American Indian (AI; N = 883), European American (EA; N = 537), and Mexican American (MA; N = 1634) individuals from the Family Investigation of Nephropathy and Diabetes. Non-parametric linkage analysis, using an average of 4404 SNPs, was performed in relative pairs affected with T2DM in each ethnic group. In addition, family-based tests were performed to detect association with T2DM.
resultsStatistically significant evidence for linkage was observed on chromosome 4q21.1 (LOD = 3.13; genome-wide p = 0.04) in AA. In addition, a total of 11 regions showed suggestive evidence for linkage (estimated at LOD > 1.71), with the highest LOD scores on chromosomes 12q21.31 (LOD = 2.02) and 22q12.3 (LOD = 2.38) in AA, 2p11.1 (LOD = 2.23) in AI, 6p12.3 (LOD = 2.77) in EA, and 13q21.1 (LOD = . 2.24) in MA. While no region overlapped across all ethnic groups, at least five loci showing LOD > 1.71 have been identified in previously published studies.
conclusionsThe results from this study provide evidence for the presence of genes affecting T2DM on chromosomes 4q, 12q, and 22q in AA; 6p in EA; 2p in AI; and 13q in MA. The strong evidence for linkage on chromosome 4q in AA provides important information given the paucity of diabetes genetic studies in this population.
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