ArticleJournal of bioenergetics and biomembranes2009
Mitochondrial haplogroups associated with Japanese Alzheimer's patients.
Article in Journal of bioenergetics and biomembranes, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Mitochondrial DNA and Alzheimer's disease: a first case-control study of the Tunisian population.Molecular biology reports · 2022Article
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- Mitophagy and the Brain.International journal of molecular sciences · 2020Review
- The Application of Artificial Intelligence in the Genetic Study of Alzheimer's Disease.Aging and disease · 2020Review
- The Genomic Origins of Small Mitochondrial RNAs: Are They Transcribed by the Mitochondrial DNA or by Mitochondrial Pseudogenes within the Nucleus (NUMTs)?Genome biology and evolution · 2019Article
- Contribution of Mitochondrial DNA Variation to Chronic Disease in East Asian Populations.Frontiers in molecular biosciences · 2019Review
- Assembly of 809 whole mitochondrial genomes with clinical, imaging, and fluid biomarker phenotyping.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018Article
- Mitochondria and Alzheimer's Disease: the Role of Mitochondrial Genetic Variation.Current genetic medicine reports · 2018Review
- Mitochondria, Cybrids, Aging, and Alzheimer's Disease.Progress in molecular biology and translational science · 2017Review
- The Alzheimer's disease mitochondrial cascade hypothesis: progress and perspectives.Biochimica et biophysica acta · 2014Review
- The impact of mitochondrial DNA and nuclear genes related to mitochondrial functioning on the risk of Parkinson's disease.Current genomics · 2013Article
- Genetics of Alzheimer's disease.BioMed research international · 2013Review
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- Mitochondria and cell bioenergetics: increasingly recognized components and a possible etiologic cause of Alzheimer's disease.Antioxidants & redox signaling · 2012Review
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- Genomics of Dementia: APOE- and CYP2D6-Related Pharmacogenetics.International journal of Alzheimer's disease · 2012Article
- Mitochondrial matters of the brain: amyloid formation and Alzheimer's disease introduction.Journal of bioenergetics and biomembranes · 2009Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationships between Japanese Alzheimer's disease (AD) patients and their mitochondrial single nucleotide polymorphism (mtSNP) frequencies at individual mtDNA positions of the entire mitochondrial genome are described using the radial basis function (RBF) network and the modified method. Japanese AD patients are associated with the haplogroups G2a, B4c1, and N9b1. In addition, to compare mitochondrial haplogroups of the AD patients with those of other classes of Japanese people, the relationships between four classes of Japanese people (i.e., Japanese centenarians, Parkinson's disease (PD) patients, type 2 diabetic (T2D) patients, and non-obese young males) and their mtSNPs are also described. The four classes of people are associated with following haplogroups: Japanese centenarians-M7b2, D4b2a, and B5b; Japanese PD patients-M7b2, B4e, and B5b; Japanese T2D patients-B5b, M8a1, G, D4, and F1; and Japanese healthy non-obese young males-D4g and D4b1b. The haplogroups of the AD patients are therefore different from those of the other four classes of Japanese people. As the analysis method described in this article can predict a person's mtSNP constitution and the probabilities of becoming an AD patient, centenarian, PD patient, or T2D patient, it may be useful in initial diagnosis of various diseases.
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