ReviewJournal of clinical immunology2009
Autoimmunity, infectious immunity, and atherosclerosis.
Review in Journal of clinical immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Helicobacter pylori infection contributes to high risk of ischemic stroke: evidence from a meta-analysis.Journal of neurology · 2012Pooled it
- ACTH- and cortisol-associated neutrophil modulation in coronary artery disease patients undergoing stent implantation.PloS one · 2013Trial
- Glucolipid Metabolic Disorders andInternational journal of endocrinology · 2026Review
- Cardiovascular and Neurological Diseases and Association with Helicobacter Pylori Infection-An Overview.Diagnostics (Basel, Switzerland) · 2024Review
- Searching for serum biomarkers linking coronary heart disease and Helicobacter pylori infection using infrared spectroscopy and artificial neural networks.Scientific reports · 2022Article
- Infections as Novel Risk Factors of Atherosclerotic Cardiovascular Diseases: Pathophysiological Links and Therapeutic Implications.Journal of clinical medicine · 2021Review
- Role of Fluid Milk in Attenuating Postprandial Hyperglycemia and Hypertriglyceridemia.Nutrients · 2020Review
- Review
- Nature and nurture in atherosclerosis: The roles of acylcarnitine and cell membrane-fatty acid intermediates.Vascular pharmacology · 2016 · on this mapReview
- Putative consequences of exposure to Helicobacter pylori infection in patients with coronary heart disease in terms of humoral immune response and inflammation.Archives of medical science : AMS · 2016Article
- Helicobacter pylori vs coronary heart disease - searching for connections.World journal of cardiology · 2015Article
- Autoantibodies targeting AT1 receptor from patients with acute coronary syndrome upregulate proinflammatory cytokines expression in endothelial cells involving NF-κB pathway.Journal of immunology research · 2014Article
- Gastric autoantigenic proteins in Helicobacter pylori infection.Yonsei medical journal · 2013Article
- Auto-antibodies as emergent prognostic markers and possible mediators of ischemic cardiovascular diseases.Clinical reviews in allergy & immunology · 2013Review
- Multiparametric assessment of vascular function and atherosclerosis in patients with autoimmune gastritis: a comparative study.Digestive diseases and sciences · 2011Article
- Seroprevalence of 13 common pathogens in a rapidly growing U.S. minority population: Mexican Americans from San Antonio, TX.BMC research notes · 2011Article
- Emerging role of IL-17 in atherosclerosis.Journal of innate immunity · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionVascular inflammation is common in certain systemic autoimmune diseases and contributes to the oxidation of low-density lipoprotein (oxLDL) and oxLDL/beta2-glycoprotein I (beta2GPI) complex formation. These complexes have been implicated as proatherogenic autoantigens that participate in the development of atherosclerotic disease. DISCUSSION: We have demonstrated that the in vitro macrophage uptake of oxLDL/beta2GPI complexes increases in the presence of IgG anti-beta2GPI antibodies and that IgG immune complexes containing oxLDL/beta2GPI upregulate the expression of both scavenger and Fcgamma receptors to activate beta2GPI specific T cells. Some persistent infections may cause immune responses that promote atherogenesis. Cellular immunity (Th1) against Helicobacter pylori (H. pylori) derived heat shock protein 60 (Hp-HSP60) cross-reacts with endogenous HSP60 to cause cardiovascular disease likely by molecular mimicry.
conclusionInfectious cellular response may be proatherogenic,while the humoral response (antibody production) maybe protective. We review the recent progress in our understanding of autoimmunity and infectious immunity that promote atherosclerosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.