ArticleMolecular imaging and biology2010
COMT Val158Met genotype does not alter cortical or striatal dopamine D2 receptor availability in vivo.
Article in Molecular imaging and biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetic variation and dopamine D2 receptor availability: a systematic review and meta-analysis of human in vivo molecular imaging studies.Translational psychiatry · 2016Pooled it
- Cortical Dopamine Transmission as Measured with the [11C]FLB 457 - Amphetamine PET Imaging Paradigm Is Not Influenced by COMT Genotype.PloS one · 2016Trial
- Lifespan longitudinal changes in mesocortical thickness and executive function: Role of dopaminergic genetic predisposition.Neurobiology of aging · 2025Article
- Catechol-O-methyltransferase activity in individuals with substance use disorders: a case control study.BMC psychiatry · 2022Article
- Role of COMT V158M Polymorphism in the Development of Dystonia after Administration of Antipsychotic Drugs.Brain sciences · 2021Article
- Cortical thickness mediates the relationship between DRD2 C957T polymorphism and executive function across the adult lifespan.Brain structure & function · 2021Article
- Frontoparietal cortical thickness mediates the effect of COMT ValNeurobiology of aging · 2019Article
- Binge-Like Alcohol Exposure During Adolescence Disrupts Dopaminergic Neurotransmission in the Adult Prelimbic Cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- The Role of Genes, Stress, and Dopamine in the Development of Schizophrenia.Biological psychiatry · 2017Review
- The role of the COMT val158met polymorphism in mediating aversive learning in visual cortex.NeuroImage · 2016Article
- Gene-sex interactions in schizophrenia: focus on dopamine neurotransmission.Frontiers in behavioral neuroscience · 2014Review
- Article
- Human fear reconsolidation and allelic differences in serotonergic and dopaminergic genes.Translational psychiatry · 2012Article
- A quantitative way to estimate clinical off-target effects for human membrane brain targets in CNS research and development.Journal of experimental pharmacology · 2012Article
- Dysfunctional brain networks and genetic risk for schizophrenia: specific neurotransmitter systems.CNS neuroscience & therapeutics · 2011Review
- Genetically determined measures of striatal D2 signaling predict prefrontal activity during working memory performance.PloS one · 2010Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCatechol-O-methyl transferase (COMT) is a pivotal regulator of brain dopamine function with a region-specific role. COMT is important in dopamine elimination in the prefrontal cortex, whereas dopamine reuptake is the main mechanism for synaptic removal of dopamine in the striatum. We studied whether the functional COMT gene polymorphism (Val158Met) associates with altered dopamine D2 receptor binding characteristics in vivo hypothesizing an effect in the cortex but not in the striatum. PROCEDURES: Samples of 38 and 45 Finnish healthy subjects scanned previously with PET and the D2/D3 receptor radioligands [(11)C]FLB457 or [(11)C]raclopride, respectively, were genotyped for the Val158Met polymorphism.
resultsNo significant associations were found between the Val158Met genotype and D2 receptor binding characteristics in the cortex or the striatum as measured with [(11)C]FLB457 and [(11)C]raclopride, respectively.
conclusionsCOMT genotype is not related with alterations in baseline D2 receptor availability in vivo in the cortex or the striatum. This information is useful for the interpretation of genetic studies on COMT in neuropsychiatry.
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Registered trials
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