ReviewDeutsches Arzteblatt international2009
Gout--current diagnosis and treatment.
Review in Deutsches Arzteblatt international, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 6 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Effect of tea intake on genetic predisposition to gout and uric acid: a Mendelian randomization study.Frontiers in endocrinology · 2023Pooled it
- Diagnosis and treatment for hyperuricemia and gout: a systematic review of clinical practice guidelines and consensus statements.BMJ open · 2019Pooled it
- Diagnostic accuracy of dual-energy CT and ultrasound in gouty arthritis : A systematic review.Zeitschrift fur Rheumatologie · 2017Pooled it
- A Systematic Review of the Economic and Humanistic Burden of Gout.PharmacoEconomics · 2015Pooled it
- Safety of allopurinol compared with other urate-lowering drugs in patients with gout: a systematic review and meta-analysis.Rheumatology international · 2015Pooled it
- Association between gout and all-cause as well as cardiovascular mortality: a systematic review.Current rheumatology reports · 2012Pooled it
- Gout flares, serum urate and seasonality: a descriptive cohort study.Clinical rheumatology · 2026Article
- The effects ofFrontiers in microbiology · 2025Article
- IL1A regulates the inflammation in gout through the Toll-like receptors pathway.International journal of medical sciences · 2024Article
- Protective effects of corni fructus extract in mice with potassium oxonate-induced hyperuricemia.The Journal of veterinary medical science · 2022Article
- The Role of the Intestine in the Development of Hyperuricemia.Frontiers in immunology · 2022Review
- Serum CA72-4 is specifically elevated in gout patients and predicts flares.Rheumatology (Oxford, England) · 2020Article
- Efficacy and safety of fire-needle in the treatment of gouty arthritis: A protocol for systematic review and meta analysis.Medicine · 2020Article
- Mathematical modeling for bioprocess optimization of a protein drug, uricase, production by Aspergillus welwitschiae strain 1-4.Scientific reports · 2019Article
- Risk factors for the formation of double-contour sign and tophi in gout.Journal of orthopaedic surgery and research · 2019Article
- Side Effects and Interactions of the Xanthine Oxidase Inhibitor Febuxostat.Pharmaceuticals (Basel, Switzerland) · 2018Review
- Anti-gout Potential of Malaysian Medicinal Plants.Frontiers in pharmacology · 2018Review
- Improving adherence to gout therapy: an expert review.Therapeutics and clinical risk management · 2018Review
- Asymptomatic Papules and Subcutaneous Nodules as First Sign of Gout.Open access Macedonian journal of medical sciences · 2017Article
- Treatment Options for Gout.Deutsches Arzteblatt international · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBecause of the changing dietary habits of an aging population, hyperuricemia is frequently found in combination with other metabolic disorders. Longstanding elevation of the serum uric acid level can lead to the deposition of monosodium urate crystals, causing gout (arthritis, urate nephropathy, tophi). In Germany, the prevalence of gouty arthritis is estimated at 1.4%, higher than that of rheumatoid arthritis. There are no German guidelines to date for the treatment of gout. Its current treatment is based largely on expert opinion.
methodsSelective literature review on the diagnosis and treatment of gout. RESULTS AND
conclusionsAsymptomatic hyperuricemia is generally not an indication for pharmacological intervention to lower the uric acid level. When gout is clinically manifest, however, acute treatment of gouty arthritis should be followed by determination of the cause of hyperuricemia, and long-term treatment to lower the uric acid level is usually necessary. The goal of treatment is to diminish the body's stores of uric acid crystal deposits (the intrinsic uric acid pool) and thereby to prevent the inflammatory processes that they cause, which lead to structural alterations. In the long term, serum uric acid levels should be kept below 360 micromol/L (6 mg/dL). The available medications for this purpose are allopurinol and various uricosuric agents, e.g., benzbromarone. There is good evidence to support the treatment of gouty attacks by the timely, short-term use of non-steroidal anti-inflammatory drugs (NSAID), colchicine, and glucocorticosteroids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.