ArticleJournal of clinical biochemistry and nutrition2009
Prevention of NSAID-Induced Small Intestinal Mucosal Injury: Prophylactic Potential of Lansoprazole.
Article in Journal of clinical biochemistry and nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- The effect of rebamipide on non-steroidal anti-inflammatory drug-induced gastro-enteropathy: a multi-center, randomized pilot study.The Korean journal of internal medicine · 2022Trial
- Effects ofThe journal of poultry science · 2026Article
- Lansoprazole protects hepatic cells against cisplatin-induced oxidative stress through the p38 MAPK/ARE/Nrf2 pathway.PloS one · 2023Article
- Gaseous Mediators as a Key Molecular Targets for the Development of Gastrointestinal-Safe Anti-Inflammatory Pharmacology.Frontiers in pharmacology · 2021Review
- Non-steroidal anti-inflammatory drug-induced enteropathy.Intestinal research · 2017Review
- Proton pump inhibitor therapy did not increase the prevalence of small-bowel injury: A propensity-matched analysis.PloS one · 2017Article
- Omeprazole induces heme oxygenase-1 in fetal human pulmonary microvascular endothelial cells via hydrogen peroxide-independent Nrf2 signaling pathway.Toxicology and applied pharmacology · 2016Article
- Uncovering the uncertainty: Risk factors and clinical relevance of P1 lesions on small bowel capsule endoscopy of anemic patients.World journal of gastroenterology · 2016Article
- Renoprotective effect of lansoprazole in streptozotocin-induced diabetic nephropathy in wistar rats.Naunyn-Schmiedeberg's archives of pharmacology · 2016Article
- Effect of proton-pump inhibitors on the risk of lower gastrointestinal bleeding associated with NSAIDs, aspirin, clopidogrel, and warfarin.Journal of gastroenterology · 2015Article
- Small bowel injury in low-dose aspirin users.Journal of gastroenterology · 2015Review
- Protective role of hemeoxygenase-1 in gastrointestinal diseases.Cellular and molecular life sciences : CMLS · 2015Review
- Traditional Herbal Medicine, Rikkunshito, Induces HSP60 and Enhances Cytoprotection of Small Intestinal Mucosal Cells as a Nontoxic Chaperone Inducer.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Evidence for enhanced cytoprotective function of HSP90-overexpressing small intestinal epithelial cells.Digestive diseases and sciences · 2011Article
- Evaluation of gastrointestinal injury and blood flow of small bowel during low-dose aspirin administration.Journal of clinical biochemistry and nutrition · 2011Article
- The pathophysiology of non-steroidal anti-inflammatory drug (NSAID)-induced mucosal injuries in stomach and small intestine.Journal of clinical biochemistry and nutrition · 2011Article
- Mitochondrial disorders in NSAIDs-induced small bowel injury.Journal of clinical biochemistry and nutrition · 2011Article
- Identification of dihalogenated proteins in rat intestinal mucosa injured by indomethacin.Journal of clinical biochemistry and nutrition · 2011Article
- Heme oxygenase-1: a novel therapeutic target for gastrointestinal diseases.Journal of clinical biochemistry and nutrition · 2011Article
- Evaluation of portal hypertensive enteropathy by scoring with capsule endoscopy: is transient elastography of clinical impact?Journal of clinical biochemistry and nutrition · 2010Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-steroidal anti-inflammatory drugs (NSAIDs), which are used for the treatment of several inflammatory disorders including rheumatoid arthritis, are well known to cause gastroduodenal mucosal lesions as an adverse effect. Recently, the serious problem of NSAID-induced small intestinal damage has become a topic of great interest to gastroenterologists, since capsule endoscopy and double-balloon enteroscopy are available for the detection of small intestinal lesions. Such lesions have been of great concern in clinical settings, and their treatment and prevention must be devised as soon as possible. Proton pump inhibitors (PPI), such as lansoprazole and omeprazole, show a potent anti-secretory effect. PPIs also have a gastroprotective effect, independent of their anti-secretory actions, which is probably mediated by inhibition of neutrophil functions as well as antioxidant actions. Administration of lansoprazole reduced the severity of the intestinal lesions in a dose-dependent manner, but omeprazole had no effect. The amount of heme oxygenase-1 (HO-1) protein in the intestinal mucosa was significantly increased by lansoprazole, but not by omeprazole. These results suggest that lansoprazole, but not omeprazole, ameliorates indomethacin-induced small intestinal ulceration through upregulation of HO-1/carbon monoxide. Therefore, lansoprazole may be useful for preventing the adverse effects of NSAIDs not only in the stomach but also in the small intestine.
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