ArticleOrganogenesis2009
Adipose tissue-organotypic culture system as a promising model for studying adipose tissue biology and regeneration.
Article in Organogenesis, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Bioprinting functional fat - adipocytes as the next frontier in tissue engineering, regenerative medicine, and cultivated meat.Frontiers in bioengineering and biotechnology · 2026Review
- Extending the Three-Dimensional Culture of Adipocytes Through Surface Coatings.Bioengineering (Basel, Switzerland) · 2025Article
- BuildingSTAR protocols · 2022Article
- High-throughput drug screening models of mature adipose tissues which replicate the physiology of patients' Body Mass Index (BMI).Bioactive materials · 2022Article
- Systems for Muscle Cell Differentiation: From Bioengineering to Future Food.Micromachines · 2021Review
- Microfragmented adipose tissue is associated with improved ex vivo performance linked to HOXB7 and b-FGF expression.Stem cell research & therapy · 2021Article
- Article
- D-Mannose Inhibits Adipogenic Differentiation of Adipose Tissue-Derived Stem CellsStem cells international · 2020Article
- Melatonin and Vitamin D Interfere with the Adipogenic Fate of Adipose-Derived Stem Cells.International journal of molecular sciences · 2017Article
- Article
- The Use of Silk as a Scaffold for Mature, Sustainable Unilocular Adipose 3D Tissue Engineered Systems.Advanced healthcare materials · 2016Article
- Characterization of In Vitro Engineered Human Adipose Tissues: Relevant Adipokine Secretion and Impact of TNF-α.PloS one · 2015Article
- Adipose tissue engineering in three-dimensional levitation tissue culture system based on magnetic nanoparticles.Tissue engineering. Part C, Methods · 2013Article
- Effects of vitamin A on in vitro maturation of pre-pubertal mouse spermatogonial stem cells.PloS one · 2013Article
- Human periprostatic adipose tissue promotes prostate cancer aggressiveness in vitro.Journal of experimental & clinical cancer research : CR · 2012Article
- Culture models for studying thyroid biology and disorders.ISRN endocrinology · 2011Article
Corrections and comments
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Authors and funding
9 authors.
Funding
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Abstract
Adipose tissue consists of mature adipocytes, preadipocytes and mesenchymal stem cells (MSCs), but a culture system for analyzing their cell types within the tissue has not been established. We have recently developed "adipose tissue-organotypic culture system" that maintains unilocular structure, proliferative ability and functions of mature adipocytes for a long term, using three-dimensional collagen gel culture of the tissue fragments. In this system, both preadipocytes and MSCs regenerate actively at the peripheral zone of the fragments. Our method will open up a new way for studying both multiple cell types within adipose tissue and the cell-based mechanisms of obesity and metabolic syndrome. Thus, it seems to be a promising model for investigating adipose tissue biology and regeneration. In this article, we introduce adipose tissue-organotypic culture, and propose two theories regarding the mechanism of tissue regeneration that occurs specifically at peripheral zone of tissue fragments in vitro.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.