ArticleOrganogenesis2009
Three-dimensional culture models of mammary gland.
Article in Organogenesis, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- In vivo assessment of number of milk duct orifices in lactating women and association with parameters in the mother and the infant.BMC pregnancy and childbirth · 2014Trial
- From inserts to 3D spheroids: MAC-T and BME-UV1 co-culture models for in vitro reconstruction of the bovine mammary epithelial architecture.Veterinary research · 2026Article
- β-Hydroxybutyrate promotes chemoresistance and proliferation in breast cancer cells.Biochemistry and biophysics reports · 2025Article
- Review
- Accelerating whole-sample polarization-resolved second harmonic generation imaging in mammary gland tissue via generative adversarial networks.Biomedical optics express · 2024Article
- Bioengineering in salivary gland regeneration.Journal of biomedical science · 2022Review
- Mammary gland 3D cell culture systems in farm animals.Veterinary research · 2021Review
- PtdIns(3,4,5)PProceedings of the National Academy of Sciences of the United States of America · 2020Article
- 3D culture models for studying branching morphogenesis in the mammary gland and mammalian lung.Biomaterials · 2019Review
- Luminal MCF-12A & myoepithelial-like Hs 578Bst cells form bilayered acini similar to human breast.Future science OA · 2018Article
- Article
- Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss.Genes & development · 2016Article
- Advances in 3D cell culture technologies enabling tissue-like structures to be created in vitro.Journal of anatomy · 2015Review
- Review
- Essential Role for Zinc Transporter 2 (ZnT2)-mediated Zinc Transport in Mammary Gland Development and Function during Lactation.The Journal of biological chemistry · 2015Article
- A proposal of an in vitro model which mimics in situ areas of carcinoma.Journal of cell communication and signaling · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The mammary gland is a complex tissue comprised of a branching network of ducts embedded within an adipocyte-rich stroma. The ductal epithelium is a bi-layer of luminal and myoepithelial cells, the latter being in contact with a basement membrane. During pregnancy, tertiary branching occurs and lobuloalveolar structures, which produce milk during lactation, form in response to hormonal and cytokine signals. Postlactational regression is characterized by extensive cell death and tissue remodeling. These complex developmental events have been difficult to mimic in cell culture although many useful culture models exist. Recently, considerable advances in three-dimensional modelling of the mammary gland have been made with the use of collagen and other biomaterials for the study of branching morphogenesis and tumorigenesis, techniques which may enable rapid advances in our understanding of both basic biology and the study of cancer therapeutics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.