ArticleHPB surgery : a world journal of hepatic, pancreatic and biliary surgery2009
Influence of portosystemic shunt on liver regeneration after hepatic resection in pigs.
Article in HPB surgery : a world journal of hepatic, pancreatic and biliary surgery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Computed Tomographic Hepatic Volumetry in Dogs with Congenital Portosystemic Shunts.Veterinary sciences · 2024Article
- Portocaval shunt can optimize transhepatic flow following extended hepatectomy: a short-term study in a porcine model.Scientific reports · 2022Article
- 2021 ISHEN guidelines on animal models of hepatic encephalopathy.Liver international : official journal of the International Association for the Study of the Liver · 2021Review
- "Small-for-Flow" Syndrome: Concept Evolution.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2020Review
- Doxazosin and Carvedilol Treatment Improves Hepatic Regeneration in a Hamster Model of Cirrhosis.BioMed research international · 2018Article
- Response to: Comment on "Establishing a Porcine Model of Small for Size Syndrome following Liver Resection".Canadian journal of gastroenterology & hepatology · 2018Article
- Hepatic Hemodynamic Changes Following Stepwise Liver Resection.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe minimal amount of liver mass necessary for regeneration is still a matter of debate. The aim of the study was to analyze liver regeneration factors after extended resection with or without portosystemic shunt.
methodsAn extended left hemihepatectomy was performed in 25 domestic pigs, in 15 cases after a portosystemic H-shunt. The expression of Ki-67, VEGF, TGF-alpha, FGF, and CK-7 was analyzed in paraffin-embedded tissue sections.
resultsThe volume of the remnant liver increased about 2.5-fold at the end of the first week after resection. With 19 cells/10 Glisson fields versus 4/10, Ki-67-expression was significantly higher in the H-shunt group. VEGF- and CK-7-expressions were significantly higher in the control group. No significant change was found in FGF-expression. The expression of TGF-alpha was higher, but not significantly, in the control group.
conclusionsThe expression of Ki-67, and therefore hepatocyte regeneration, was increased in the shunt group. The expression of CK-7 on biliary epithelium and the expression of VEGF, however, were stronger in the control group.
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Registered trials
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