ArticleHFSP journal2009
Nucleocytoplasmic transport: a thermodynamic mechanism.
Article in HFSP journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Conserved nucleocytoplasmic density homeostasis drives cellular organization across eukaryotes.Nature communications · 2025Article
- Mechanical force application to the nucleus regulates nucleocytoplasmic transport.Nature cell biology · 2022Article
- Measuring and Interpreting Nuclear Transport in Neurodegenerative Disease-The Example of C9orf72 ALS.International journal of molecular sciences · 2021Review
- Physics of the Nuclear Pore Complex: Theory, Modeling and Experiment.Physics reports · 2021Article
- Enhanced Nucleocytoplasmic Transport due to Competition for Elastic Binding Sites.Biophysical journal · 2018Article
- A discontinuous Galerkin model for fluorescence loss in photobleaching of intracellular polyglutamine protein aggregates.BMC biophysics · 2018Article
- Karyopherins regulate nuclear pore complex barrier and transport function.The Journal of cell biology · 2017Article
- Two faces of competition: target-mediated reverse signalling in microRNA and mitogen-activated protein kinase regulatory networks.IET systems biology · 2017Review
- Article
- Thermodynamic Paradigm for Solution Demixing Inspired by Nuclear Transport in Living Cells.Physical review letters · 2017Article
- Dissecting in vivo steady-state dynamics of karyopherin-dependent nuclear transport.Molecular biology of the cell · 2016Article
- Disordered proteinaceous machines.Chemical reviews · 2014Review
- Enzymatically driven transport: a kinetic theory for nuclear export.Biophysical journal · 2013Article
- A simple kinetic model with explicit predictions for nuclear transport.Biophysical journal · 2013Article
- Multiscale dynamics in nucleocytoplasmic transport.Current opinion in cell biology · 2012Review
- Nuclear export dynamics of RNA-protein complexes.Nature · 2011Review
- Transportin mediates nuclear entry of DNA in vertebrate systems.Traffic (Copenhagen, Denmark) · 2009Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nuclear pore supports molecular communication between cytoplasm and nucleus in eukaryotic cells. Selective transport of proteins is mediated by soluble receptors, whose regulation by the small GTPase Ran leads to cargo accumulation in, or depletion from, the nucleus, i.e., nuclear import or nuclear export. We consider the operation of this transport system by a combined analytical and experimental approach. Provocative predictions of a simple model were tested using cell-free nuclei reconstituted in Xenopus egg extract, a system well suited to quantitative studies. We found that accumulation capacity is limited, so that introduction of one import cargo leads to egress of another. Clearly, the pore per se does not determine transport directionality. Moreover, different cargo reach a similar ratio of nuclear to cytoplasmic concentration in steady-state. The model shows that this ratio should in fact be independent of the receptor-cargo affinity, though kinetics may be strongly influenced. Numerical conservation of the system components highlights a conflict between the observations and the popular concept of transport cycles. We suggest that chemical partitioning provides a framework to understand the capacity to generate concentration gradients by equilibration of the receptor-cargo intermediary.
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Registered trials
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