ArticleAmerican journal of physiology. Cell physiology2009
IFN{gamma} regulates retinal pigment epithelial fluid transport.
Article in American journal of physiology. Cell physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01432847 (Generation of Induced Pluripotent Stem), which is not on this map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Generation of Induced Pluripotent Stem (iPS) Cell Lines From Somatic Cells of Participants With Eye Diseases and From Somatic Cells of Matched Controls
Who cites it
25 citing papers in PubMed, 40 citations in OpenAlex.
- Interferon-mediated regulation of the neurovascular unit in diabetic retinopathy.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Lipopolysaccharide enhances HSV-1 replication and inflammatory factor release in the ARPE-19 cells.Heliyon · 2022Article
- Oxidative stress and mitochondrial transfer: A new dimension towards ocular diseases.Genes & diseases · 2022Review
- Genipin protects against mitochondrial damage of the retinal pigment epithelium under hyperglycemia through theAnnals of translational medicine · 2022Article
- Aqueous humor cytokine levels through microarray analysis and a sub-analysis based on optical coherence tomography in wet age-related macular degeneration patients.BMC ophthalmology · 2021Article
- Retinal Pigment Epithelium Replacement Therapy for Age-Related Macular Degeneration: Are We There Yet?Annual review of pharmacology and toxicology · 2020Review
- Polarized Human Retinal Pigment Epithelium Exhibits Distinct Surface Proteome on Apical and Basal Plasma Membranes.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Article
- Nanofiber Scaffold-Based Tissue-Engineered Retinal Pigment Epithelium to Treat Degenerative Eye Diseases.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2016Review
- Looking into the future: Using induced pluripotent stem cells to build two and three dimensional ocular tissue for cell therapy and disease modeling.Brain research · 2016Review
- Human Adult Retinal Pigment Epithelial Stem Cell-Derived RPE Monolayers Exhibit Key Physiological Characteristics of Native Tissue.Investigative ophthalmology & visual science · 2015Article
- Potentially pathogenic immune cells and networks in apparently healthy lacrimal glands.The ocular surface · 2015Article
- An unexpected effect of TNF-α on F508del-CFTR maturation and function.F1000Research · 2015Article
- Cultured primary human fetal retinal pigment epithelium (hfRPE) as a model for evaluating RPE metabolism.Experimental eye research · 2014Review
- The retinal pigment epithelium utilizes fatty acids for ketogenesis.The Journal of biological chemistry · 2014Article
- Developing cellular therapies for retinal degenerative diseases.Investigative ophthalmology & visual science · 2014Article
- Regulation of claudins in blood-tissue barriers under physiological and pathological states.Tissue barriers · 2013Review
- Effects of proinflammatory cytokines on the claudin-19 rich tight junctions of human retinal pigment epithelium.Investigative ophthalmology & visual science · 2012Article
- Next-generation therapeutic solutions for age-related macular degeneration.Pharmaceutical patent analyst · 2012Review
- Stimulation of aquaporin-mediated fluid transport by cyclic GMP in human retinal pigment epithelium in vitro.Investigative ophthalmology & visual science · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The present experiments show that IFNgamma receptors are mainly localized to the basolateral membrane of human retinal pigment epithelium (RPE). Activation of these receptors in primary cultures of human fetal RPE inhibited cell proliferation and migration, decreased RPE mitochondrial membrane potential, altered transepithelial potential and resistance, and significantly increased transepithelial fluid absorption. These effects are mediated through JAK-STAT and p38 MAPK signaling pathways. Second messenger signaling through cAMP-PKA pathway- and interferon regulatory factor-1-dependent production of nitric oxide/cGMP stimulated the CFTR at the basolateral membrane and increased transepithelial fluid absorption. In vivo experiments using a rat model of retinal reattachment showed that IFNgamma applied to the anterior surface of the eye can remove extra fluid deposited in the extracellular or subretinal space between the retinal photoreceptors and RPE. Removal of this extra fluid was blocked by a combination of PKA and JAK-STAT pathway inhibitors injected into the subretinal space. These results demonstrate a protective role for IFNgamma in regulating retinal hydration across the outer blood-retinal barrier in inflammatory disease processes and provide the basis for possible therapeutic interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.