ArticleDiabetes2010
Infection with viruses from several families triggers autoimmune diabetes in LEW*1WR1 rats: prevention of diabetes by maternal immunization.
Article in Diabetes, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes.Diabetes · 2023Article
- The missing heritability in type 1 diabetes.Diabetes, obesity & metabolism · 2022Review
- Modeling human T1D-associated autoimmune processes.Molecular metabolism · 2022Review
- Environmental Triggering of Type 1 Diabetes Autoimmunity.Frontiers in endocrinology · 2022Review
- Visceral Adipose Tissue: A New Target Organ in Virus-Induced Type 1 Diabetes.Frontiers in immunology · 2021Review
- Epigenetic regulation of Toll-like receptors and its roles in type 1 diabetes.Journal of molecular medicine (Berlin, Germany) · 2018Review
- Article
- A Critical Role for the Type I Interferon Receptor in Virus-Induced Autoimmune Diabetes in Rats.Diabetes · 2017Article
- Innate inflammation in type 1 diabetes.Translational research : the journal of laboratory and clinical medicine · 2016Review
- Diversity in the preimmune immunoglobulin repertoire of SHR lines susceptible and resistant to end-organ injury.Genes and immunity · 2014Article
- Autoantigen-induced focusing of Vβ13+ T cells precedes onset of autoimmune diabetes in the LEW.1WR1 rat.Diabetes · 2014Article
- Temporal induction of immunoregulatory processes coincides with age-dependent resistance to viral-induced type 1 diabetes.Genes and immunity · 2013Article
- Previous maternal infection protects offspring from enterovirus infection and prevents experimental diabetes development in mice.Diabetologia · 2013Article
- Article
- The Missing Heritability in T1D and Potential New Targets for Prevention.Journal of diabetes research · 2013Article
- Prevention or acceleration of type 1 diabetes by viruses.Cellular and molecular life sciences : CMLS · 2013Review
- Infection as a cause of type 1 diabetes?Current opinion in rheumatology · 2012Review
- Article
- Paradigm shift or shifting paradigm for type 1 diabetes.Diabetes · 2012Article
- Virus infections in type 1 diabetes.Cold Spring Harbor perspectives in medicine · 2012Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveThe contribution of antecedent viral infection to the development of type 1 diabetes in humans is controversial. Using a newer rat model of the disease, we sought to 1) identify viruses capable of modulating diabetes penetrance, 2) identify conditions that increase or decrease the diabetogenicity of infection, and 3) determine whether maternal immunization would prevent diabetes. RESEARCH DESIGN AND
methodsAbout 2% of LEW*1WR1 rats develop spontaneous autoimmune diabetes, but disease penetrance is much higher if weanling rats are exposed to environmental perturbants including Kilham rat virus (KRV). We compared KRV with other viruses for diabetogenic activity.
resultsBoth KRV and rat cytomegalovirus (RCMV) induced diabetes in up to 60% of LEW*1WR1 rats, whereas H-1, vaccinia, and Coxsackie B4 viruses did not. Simultaneous inoculation of KRV and RCMV induced diabetes in 100% of animals. Pretreatment of rats with an activator of innate immunity increased the diabetogenicity of KRV but not RCMV and was associated with a moderate rate of diabetes after Coxsackie B4 and vaccinia virus infection. Inoculation of LEW*1WR1 dams with both KRV and RCMV prior to pregnancy protected weanling progeny from virus-induced diabetes in a virus-specific manner.
conclusionsExposure to viruses can affect the penetrance of autoimmune diabetes in genetically susceptible animals. The diabetogenicity of infection is virus specific and is modified by immunomodulation prior to inoculation. Maternal immunization protects weanlings from virus-induced diabetes, suggesting that modification of immune responses to infection could provide a means of preventing islet autoimmunity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.