Immunotherapy for the prevention and treatment of type 1 diabetes: human trials and a look into the future.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it.

1. Antigen-based immunotherapies do not prevent progression of recent-onset autoimmune diabetes: a systematic review and meta-analysis.Endocrine · 2016
   Pooled it
2. A randomized trial of oral gamma aminobutyric acid (GABA) or the combination of GABA with glutamic acid decarboxylase (GAD) on pancreatic islet endocrine function in children with newly diagnosed type 1 diabetes.Nature communications · 2022
   Trial
3. Nanotargeted Delivery of Immune Therapeutics in Type 1 Diabetes.Advanced materials (Deerfield Beach, Fla.) · 2023
   Article
4. Emerging Anti-Diabetic Drugs for Beta-Cell Protection in Type 1 Diabetes.Cells · 2023
   Review
5. Type 1 diabetes - What's new in prevention and therapeutic strategies?Pediatric endocrinology, diabetes, and metabolism · 2023
   Article
6. Vaccine for Diabetes-Where Do We Stand?International journal of molecular sciences · 2022
   Review
7. New Aspects of Diabetes Research and Therapeutic Development.Pharmacological reviews · 2021
   Review
8. The Confounders of Cancer Immunotherapy: Roles of Lifestyle, Metabolic Disorders and Sociological Factors.Cancers · 2020
   Review
9. Current Status on Immunological Therapies for Type 1 Diabetes Mellitus.Current diabetes reports · 2019
   Review
10. Abnormal T Cell Frequencies, Including Cytomegalovirus-Associated Expansions, Distinguish Seroconverted Subjects at Risk for Type 1 Diabetes.Frontiers in immunology · 2018
    Article
11. Human Gingiva-Derived Mesenchymal Stem Cells Ameliorate Streptozoticin-induced T1DM in mice via Suppression of T effector cells and Up-regulating Treg Subsets.Scientific reports · 2017
    Article
12. Immunotherapy for type 1 diabetes.Journal of endocrinological investigation · 2017
    Review
13. Glucocorticoids did not reverse type 1 diabetes mellitus secondary to pembrolizumab in a patient with metastatic melanoma.BMJ case reports · 2016
    Article
14. Spontaneous complete remission of type 1 diabetes mellitus in an adult - review and case report.Journal of community hospital internal medicine perspectives · 2015
    Article
15. B7-H4 as a protective shield for pancreatic islet beta cells.World journal of diabetes · 2014
    Review
16. Current status of clinical islet transplantation.World journal of transplantation · 2013
    Article
17. Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes.Science translational medicine · 2013
    Article
18. Biologic agents in islet transplantation.Current diabetes reports · 2013
    Review
19. The clinical utility of C-peptide measurement in the care of patients with diabetes.Diabetic medicine : a journal of the British Diabetic Association · 2013
    Review
20. Screening for insulinoma antigen 2 and zinc transporter 8 autoantibodies: a cost-effective and age-independent strategy to identify rapid progressors to clinical onset among relatives of type 1 diabetic patients.Clinical and experimental immunology · 2013
    Article

Corrections and comments

• Comment on
  Immunotherapy for the prevention and treatment of type 1 diabetes: optimizing the path from bench to bedside.2009

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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