ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Functional and anatomical reorganization of the sensory-motor cortex after incomplete spinal cord injury in adult rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 1 of them a synthesis that pooled it.
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91 citing papers in PubMed, 1 synthesis or guideline pooled it, 177 citations in OpenAlex.
- Exercise therapy can effectively improve trunk performance and sitting balance in spinal cord injury: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Pooled it
- Intensity dependent effects of transcranial direct current stimulation on corticospinal excitability in chronic spinal cord injury.Archives of physical medicine and rehabilitation · 2015Trial
- Aberrant crossed corticospinal facilitation in muscles distant from a spinal cord injury.PloS one · 2013Trial
- Changes in Cerebral Glucose Metabolism at Rest Following Hemicontusive Cervical Spinal Cord Injury in Mice: A Whole-Brain Autoradiographic Study.The European journal of neuroscience · 2026Article
- Enhanced sensorimotor cortex responsiveness to nonplegic hand stimulation and motor network assembly during recovery after spinal cord injury in primates.Scientific reports · 2026Article
- Enhanced Reticulospinal Output in Subacute Spinal Cord Injury Patients with Spasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Sensory Deficits in Mice with Lateral Spinal Cord Hemisection Mimic the Brown-Séquard Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Edonerpic maleate enhances functional recovery from spinal cord injury with cortical reorganization in non-human primates.Brain communications · 2025Article
- The diversity and plasticity of descending motor pathways rewired after stroke and trauma in rodents.Frontiers in neural circuits · 2025Review
- Compensatory adaptation of parallel motor pathways promotes skilled forelimb recovery after spinal cord injury.iScience · 2024Article
- Article
- Synaptotagmin 4 Supports Spontaneous Axon Sprouting after Spinal Cord Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- In vivo imaging in mouse spinal cord reveals that microglia prevent degeneration of injured axons.Nature communications · 2024Article
- Longitudinal Imaging of Injured Spinal Cord Myelin and White Matter with 3D Ultrashort Echo Time Magnetization Transfer (UTE-MT) and Diffusion MRI.Journal of imaging · 2024Article
- MicroRNA-133b Dysregulation in a Mouse Model of Cervical Contusion Injury.International journal of molecular sciences · 2024Article
- Motor Pathways Reorganization following Surgical Decompression for Degenerative Cervical Myelopathy: A Combined Navigated Transcranial Magnetic Stimulation and Clinical Outcome Study.Brain sciences · 2024Article
- Cross-hemicord spinal fiber reorganization associates with cortical sensory and motor network expansion in the rat model of hemicontusion cervical spinal cord injury.Neuroscience letters · 2024Article
- Brain Network Alterations in Chronic Spinal Cord Injury: Multilayer Community Detection Approach.Neurotrauma reports · 2024Article
- Neuropathic pain following spinal cord hemisection induced by the reorganization in primary somatosensory cortex and regulated by neuronal activity of lateral parabrachial nucleus.CNS neuroscience & therapeutics · 2023Article
31 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A lateral hemisection injury of the cervical spinal cord results in Brown-Séquard syndrome in humans and rats. The hands/forelimbs on the injured side are rendered permanently impaired, but the legs/hindlimbs recover locomotor functions. This is accompanied by increased use of the forelimb on the uninjured side. Nothing is known about the cortical circuits that correspond to these behavioral adaptations. In this study, on adult rats with cervical spinal cord lateral hemisection lesions (at segment C3/4), we explored the sensory representation and corticospinal projection of the intact (ipsilesional) cortex. Using blood oxygenation level-dependent functional magnetic resonance imaging and voltage-sensitive dye (VSD) imaging, we found that the cortex develops an enhanced representation of the unimpaired forepaw by 12 weeks after injury. VSD imaging also revealed the cortical spatio-temporal dynamics in response to electrical stimulation of the ipsilateral forepaw or hindpaw. Interestingly, stimulation of the ipsilesional hindpaw at 12 weeks showed a distinct activation of the hindlimb area in the intact, ipsilateral cortex, probably via the injury-spared spinothalamic pathway. Anterograde tracing of corticospinal axons from the intact cortex showed sprouting to recross the midline, innervating the spinal segments below the injury in both cervical and lumbar segments. Retrograde tracing of these midline-crossing axons from the cervical spinal cord (at segment C6/7) revealed the formation of a new ipsilateral forelimb representation in the cortex. Our results demonstrate profound reorganizations of the intact sensory-motor cortex after unilateral spinal cord injury. These changes may contribute to the behavioral adaptations, notably for the recovery of the ipsilesional hindlimb.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.