ArticleJournal of neurophysiology2009
Electrophysiological and pharmacological properties of locomotor activity-related neurons in cfos-EGFP mice.
Article in Journal of neurophysiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- Synergistic mechanisms of medullary cholinergic-serotonergic pathway interactions in regulating neuronal excitability and locomotor activities.Communications biology · 2025Article
- Exercise-induced adaptation of neurons in the vertebrate locomotor system.Journal of sport and health science · 2024Review
- Cholinergic modulation of persistent inward currents is mediated by activating muscarinic receptors of serotonergic neurons in the brainstem of ePet-EYFP mice.Experimental brain research · 2022Article
- Identification of adult spinal Shox2 neuronal subpopulations based on unbiased computational clustering of electrophysiological properties.Frontiers in neural circuits · 2022Article
- The effects of membrane potential oscillations on the excitability of rat hypoglossal motoneurons.Frontiers in physiology · 2022Article
- Spinal Cord Injury Alters Spinal Shox2 Interneurons by Enhancing Excitatory Synaptic Input and Serotonergic Modulation While Maintaining Intrinsic Properties in Mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Recent Insights into the Rhythmogenic Core of the Locomotor CPG.International journal of molecular sciences · 2021Review
- Overexpression of mGluR7 in the Prefrontal Cortex Attenuates Autistic Behaviors in Mice.Frontiers in cellular neuroscience · 2021Article
- Serotonergic Modulation of Persistent Inward Currents in Serotonergic Neurons of Medulla in ePet-EYFP Mice.Frontiers in neural circuits · 2021Article
- A modeling study of spinal motoneuron recruitment regulated by ionic channels during fictive locomotion.Journal of computational neuroscience · 2020Article
- Three-Week Treadmill Exercise Enhances Persistent Inward Currents, Facilitates Dendritic Plasticity, and Upregulates the Excitability of Dorsal Raphe Serotonin Neurons in ePet-EYFP Mice.Frontiers in cellular neuroscience · 2020Article
- Morphological and electrophysiological properties of serotonin neurons with NMDA modulation in the mesencephalic locomotor region of neonatal ePet-EYFP mice.Experimental brain research · 2019Article
- Three-week treadmill training changes the electrophysiological properties of spinal interneurons in the mice.Experimental brain research · 2019Article
- Balanced cholinergic modulation of spinal locomotor circuits via M2 and M3 muscarinic receptors.Scientific reports · 2019Article
- Pathological changes of distal motor neurons after complete spinal cord injury.Molecular brain · 2019Article
- Choice for Drug or Natural Reward Engages Largely Overlapping Neuronal Ensembles in the Infralimbic Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Nonreciprocal mechanisms in up- and downregulation of spinal motoneuron excitability by modulators of KCNQ/Kv7 channels.Journal of neurophysiology · 2016Article
- [Patterns of action potential firing in cortical neurons of neonatal mice and their electrophysiological property].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2016Article
- Spinal neuronal activation during locomotor-like activity enabled by epidural stimulation and 5-hydroxytryptamine agonists in spinal rats.Journal of neuroscience research · 2015Article
- Cholinergic mechanisms in spinal locomotion-potential target for rehabilitation approaches.Frontiers in neural circuits · 2014Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Although locomotion is known to be generated by networks of spinal neurons, knowledge of the properties of these neurons is limited. Using neonatal transgenic mice that express enhanced green fluorescent protein (EGFP) driven by the c-fos promoter, we visualized EGFP-positive neurons in spinal cord slices from animals that were subjected to a locomotor task or drug cocktail [N-methyl-D-aspartate, serotonin (5-HT), dopamine, and acetylcholine (ACh)]. The activity-dependent expression of EGFP was also induced in dorsal root ganglion neurons with electrical stimulation of the neurons. Following 60-90 min of swimming, whole cell patch-clamp recordings were made from EGFP+ neurons in laminae VII, VIII, and X from slices of segments T(12) to L(4). The EGFP+ neurons (n = 55) could be classified into three types based on their responses to depolarizing step currents: single spike, phasic firing, and tonic firing. Membrane properties observed in these neurons include hyperpolarization-activated inward currents (29/55), postinhibitory rebound (11/55), and persistent-inward currents (31/55). Bath application of 10-40 microM 5-HT and/or ACh increased neuronal excitability or output with hyperpolarization of voltage threshold and changes in membrane potential. 5-HT also increased input resistance, reduced the afterhyperpolarization (AHP), and induced membrane oscillations, whereas ACh reduced the input resistance and increased the AHP. In this study, we demonstrate a new way of identifying neurons active in locomotion. Our results suggest that the EGFP+ neurons are a heterogeneous population of interneurons. The actions of 5-HT and ACh on these neurons provide insights into the neuronal properties modulated by these transmitters for generation of locomotion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.