ArticleJournal of neurophysiology2009
High-amplitude positive spikes recorded extracellularly in cat visual cortex.
Article in Journal of neurophysiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 52 citations in OpenAlex.
- Extracellular Spike Waveforms: Morphology, Biophysics, and Classification Strategies.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Cortical state contributions to neuronal response variability in the early visual cortex: A system identification approach.PLoS computational biology · 2025Article
- Decomposition of retinal ganglion cell electrical images for cell type and functional inference.bioRxiv : the preprint server for biology · 2025Article
- Article
- DREDge: robust motion correction for high-density extracellular recordings across species.Nature methods · 2025Article
- The wave nature of the action potential.Frontiers in cellular neuroscience · 2025Article
- MEA-Based Graph Deviation Network for Early Autism Syndrome Signatures in Human Forebrain Organoids.Cyborg and bionic systems (Washington, D.C.) · 2025Article
- More than expected: extracellular waveforms and functional responses in monkey LGN.bioRxiv : the preprint server for biology · 2024Article
- A deep-learning strategy to identify cell types across species from high-density extracellular recordings.bioRxiv : the preprint server for biology · 2024Article
- DREDge: robust motion correction for high-density extracellular recordings across species.bioRxiv : the preprint server for biology · 2023Article
- Positive and biphasic extracellular waveforms correspond to return currents and axonal spikes.Communications biology · 2023Article
- Characterization of extracellular spike waveforms recorded in wallaby primary visual cortex.Frontiers in neuroscience · 2023Review
- An automated method for precise axon reconstruction from recordings of high-density micro-electrode arrays.Journal of neural engineering · 2022Article
- Neurophysiological Characterization of Posteromedial Hypothalamus in Anaesthetized Patients.Brain sciences · 2021Article
- Article
- Collective Synchronous Spiking in a Brain Network of Coupled Nonlinear Oscillators.Physical review letters · 2021Article
- Adult-like neural representation of species-specific songs in the auditory forebrain of zebra finch nestlings.Developmental neurobiology · 2021Article
- Brain-to-brain communication: the possible role of brain electromagnetic fields (As a Potential Hypothesis).Heliyon · 2021Review
- Features of Action Potentials from Identified Thalamic Nuclei in Anesthetized Patients.Brain sciences · 2020Article
- Human Cerebrospinal Fluid Induces Neuronal Excitability Changes in Resected Human Neocortical and Hippocampal Brain Slices.Frontiers in neuroscience · 2020Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
We simulated the shape and amplitude of extracellular action potentials (APs or "spikes") using biophysical models based on detailed reconstructions of single neurons from the cat's visual cortex. We compared these predictions with spikes recorded from the cat's primary visual cortex under a standard protocol. The experimental data were derived from a large number of neurons throughout all layers. The majority of spikes were biphasic, with a dominant negative peak (mean amplitude, -0.11 mV), whereas a minority of APs had a dominant positive peak of +0.54-mV mean amplitude, with a maximum of +1.5 mV. The largest positive amplitude spikes were recorded in layer 5. The simulations demonstrated that a pyramidal neuron under known biophysical conditions may generate a negative peak with amplitude up to -1.5 mV, but that the amplitude of the positive peak may be at most 0.5 mV. We confirmed that spikes with large positive peaks were not produced by juxtacellular patch recordings. We conclude that there is a significant gap in our present understanding of either the spike-generation process in pyramidal neurons, the biophysics of extracellular recording, or both.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.