ReviewSchizophrenia bulletin2009
Scents and nonsense: olfactory dysfunction in schizophrenia.
Review in Schizophrenia bulletin, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 133 citations in OpenAlex.
- Olfactory Dysfunction in Neurodevelopmental Disorders: A Meta-analytic Review of Autism Spectrum Disorders, Attention Deficit/Hyperactivity Disorder and Obsessive-Compulsive Disorder.Journal of autism and developmental disorders · 2020Pooled it
- Comprehensive analysis of interactions between brain aging and late-onset psychoses using heuristic mapping models.Communications medicine · 2026Article
- Exploration of Olfaction and ChiPSO in Pediatric Cystic Fibrosis.Journal of clinical medicine · 2025Article
- Neuronal Populations Involved in Motor Function Show Prominent Expression of Sbno1 During Postnatal Brain Development.Journal of developmental biology · 2025Article
- TransgenicCurrent issues in molecular biology · 2024Article
- Exploring causal mechanisms of psychosis risk.Neuroscience and biobehavioral reviews · 2024Review
- Inflammation-related pathology in the olfactory epithelium: its impact on the olfactory system in psychotic disorders.Molecular psychiatry · 2024Article
- Significant improvements in the olfactory sensitivity of bipolar I disorder patients during euthymia versus manic episodes: a longitudinal study.Frontiers in psychiatry · 2024Article
- fNIRS a novel neuroimaging tool to investigate olfaction, olfactory imagery, and crossmodal interactions: a systematic review.Frontiers in neuroscience · 2024Review
- Headache-Associated Phantosmia as a Harbinger of Lewy Body Dementia.The Journal of neuropsychiatry and clinical neurosciences · 2023Article
- Pleasant and unpleasant odor identification ability is associated with distinct dimensions of negative symptoms transdiagnostically in psychotic disorders.Schizophrenia research · 2022Article
- Association between cognition and color discrimination among Lebanese patients with schizophrenia.BMC psychiatry · 2022Article
- Abnormal sensory perception masks behavioral performance of Grin1 knockdown mice.Genes, brain, and behavior · 2022Article
- Modular-level alterations of single-subject gray matter networks in schizophrenia.Brain imaging and behavior · 2022Article
- International consensus statement on allergy and rhinology: Olfaction.International forum of allergy & rhinology · 2022Review
- Functional Covariance Connectivity of Gray and White Matter in Olfactory-Related Brain Regions in Parkinson's Disease.Frontiers in neuroscience · 2022Article
- Olfactory functional covariance connectivity in Parkinson's disease: Evidence from a Chinese population.Frontiers in aging neuroscience · 2022Article
- The Role of TRPA1 Channels in the Central Processing of Odours Contributing to the Behavioural Responses of Mice.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Topoisomerase IIIβ Deficiency Induces Neuro-Behavioral Changes and Brain Connectivity Alterations in Mice.International journal of molecular sciences · 2021Article
- Regional brain network and behavioral alterations in EGR3 gene transfected rat model of schizophrenia.Brain imaging and behavior · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Among the sensory modalities, olfaction is most closely associated with the frontal and temporal brain regions that are implicated in schizophrenia and most intimately related to the affective and mnemonic functions that these regions subserve. Olfactory probes may therefore be ideal tools through which to assess the structural and functional integrity of the neural substrates that underlie disease-related cognitive and emotional disturbances. Perhaps more importantly, to the extent that early sensory afferents are also disrupted in schizophrenia, the olfactory system-owing to its strategic anatomic location-may be especially vulnerable to such disruption. Olfactory dysfunction may therefore be a sensitive indicator of schizophrenia pathology and may even serve as an "early warning" sign of disease vulnerability or onset. In this article, we review the evidence supporting a primary olfactory sensory disturbance in schizophrenia. Convergent data indicate that structural and functional abnormalities extend from the cortex to the most peripheral elements of the olfactory system. These reflect, in part, a genetically mediated neurodevelopmental etiology. Gross structural and functional anomalies are mirrored by cellular and molecular abnormalities that suggest decreased or faulty innervation and/or dysregulation of intracellular signaling. A unifying mechanistic hypothesis may be the epigenetic regulation of gene expression. With the opportunity to obtain olfactory neural tissue from live patients through nasal epithelial biopsy, the peripheral olfactory system offers a uniquely accessible window through which the pathophysiological antecedents and sequelae of schizophrenia may be observed. This could help to clarify underlying brain mechanisms and facilitate identification of clinically relevant biomarkers.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.