ArticleProceedings. Biological sciences2010
Tuberculosis in Dr Granville's mummy: a molecular re-examination of the earliest known Egyptian mummy to be scientifically examined and given a medical diagnosis.
Article in Proceedings. Biological sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 105 citations in OpenAlex.
- Integrated Approach of Hematological Parameters and Glutathione as Predictors of Pulmonary TB Evolution: A Comprehensive Review.Journal of clinical medicine · 2026Review
- Association between e-health literacy and perceived importance of future pandemic preparedness in sub-saharan Africa.Scientific reports · 2024Article
- Evolution of orthopaedic diseases through four thousand three hundred years: from ancient Egypt with virtual examinations of mummies to the twenty-first century.International orthopaedics · 2024Article
- Silicosis and silicotuberculosis: Ancient diseases that are still not conquered.African journal of thoracic and critical care medicine · 2023Article
- Advances in TB testing.Advances in clinical chemistry · 2023Article
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- E1 of α-ketoglutarate dehydrogenase defends Mycobacterium tuberculosis against glutamate anaplerosis and nitroxidative stress.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Invasive versus Non Invasive Methods Applied to Mummy Research: Will This Controversy Ever Be Solved?BioMed research international · 2015Review
- Evaluation of gene mutations involved in drug resistance in mycobacterium tuberculosis strains derived from tuberculosis patients in mazandaran, iran, 2013.International journal of molecular and cellular medicine · 2014Article
- First insights into the metagenome of Egyptian mummies using next-generation sequencing.Journal of applied genetics · 2013Article
- Article
- Skeletal lesions in human tuberculosis may sometimes heal: an aid to palaeopathological diagnoses.PloS one · 2013Article
- Molecular identification of falciparum malaria and human tuberculosis co-infections in mummies from the Fayum depression (Lower Egypt).PloS one · 2013Article
- Computational genomics-proteomics and Phylogeny analysis of twenty one mycobacterial genomes (Tuberculosis & non Tuberculosis strains).Microbial informatics and experimentation · 2012Article
- Article
- Using affinity propagation for identifying subspecies among clonal organisms: lessons from M. tuberculosis.BMC bioinformatics · 2011Article
- Ancient DNA: Curse of the Pharaoh's DNA.Nature · 2011Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
'Dr Granville's mummy' was described to the Royal Society of London in 1825 and was the first ancient Egyptian mummy to be subjected to a scientific autopsy. The remains are those of a woman, Irtyersenu, aged about 50, from the necropolis of Thebes and dated to about 600 BC. Augustus Bozzi Granville (1783-1872), an eminent physician and obstetrician, described many organs still in situ and attributed the cause of death to a tumour of the ovary. However, subsequent histological investigations indicate that the tumour is a benign cystadenoma. Histology of the lungs demonstrated a potentially fatal pulmonary exudate and earlier studies attempted to associate this with particular disease conditions. Palaeopathology and ancient DNA analyses show that tuberculosis was widespread in ancient Egypt, so a systematic search for tuberculosis was made, using specific DNA and lipid biomarker analyses. Clear evidence for Mycobacterium tuberculosis complex DNA was obtained in lung tissue and gall bladder samples, based on nested PCR of the IS6110 locus. Lung and femurs were positive for specific M. tuberculosis complex cell-wall mycolic acids, demonstrated by high-performance liquid chromatography of pyrenebutyric acid-pentafluorobenzyl mycolates. Therefore, tuberculosis is likely to have been the major cause of death of Irtyersenu.
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