ReviewClinics in plastic surgery2009
The hypermetabolic response to burn injury and interventions to modify this response.
Review in Clinics in plastic surgery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
111 citing papers in PubMed, 4 syntheses or guidelines pooled it, 242 citations in OpenAlex.
- Population Pharmacokinetic Meta-Analysis and Dosing Recommendation for Meropenem in Critically Ill Patients Receiving Continuous Renal Replacement Therapy.Antimicrobial agents and chemotherapy · 2022Pooled it
- Nutritional Support with Omega-3 Fatty Acids in Burn Patients: A Systematic Review with Meta-Analysis of Randomized Controlled Trials.Nutrients · 2022Pooled it
- CNS-Spleen Axis - a Close Interplay in Mediating Inflammatory Responses in Burn Patients and a Key to Novel Burn Therapeutics.Frontiers in immunology · 2021Pooled it
- Safety and effectiveness of propranolol in severely burned patients: systematic review and meta-analysis.World journal of emergency surgery : WJES · 2017Pooled it
- FIVE-YEAR OUTCOMES AFTER LONG-TERM OXANDROLONE ADMINISTRATION IN SEVERELY BURNED CHILDREN: A RANDOMIZED CLINICAL TRIAL.Shock (Augusta, Ga.) · 2016Trial
- Use of 1H-nuclear magnetic resonance to screen a set of biomarkers for monitoring metabolic disturbances in severe burn patients.Critical care (London, England) · 2014Trial
- Endocrine disruptions in thermal injuries: exploring immune system interactions.Physiological reviews · 2026Review
- Bibliometric Analysis of the 100 Most-cited Publications in Burn Surgery: Analysis of Web of Science Databases.Plastic and reconstructive surgery. Global open · 2026Article
- Association Between Preoperative Core Temperature and Postoperative Mortality in Patients with Major Burns.Journal of clinical medicine · 2026Article
- Cannabis Intoxication Does Not Impact Nutritional Status in Patients With Small Burns.Journal of burn care & research : official publication of the American Burn Association · 2026Article
- Effect of a 6-Week Structured Exercise Intervention on TNF-α During the Chronic Recovery Phase of a Burn Injury Compared to Regular Daily Activities: A Pilot Randomised Cross-Over Trial.European burn journal · 2026Article
- Obesity significantly elevates thromboembolism risk in severe trauma, yet essential resuscitation with TXA and erythrocytes remains safe.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Hypermetabolism and Lipid Alterations Postburn: A Cardiovascular Perspective.Cardiovascular therapeutics · 2026Review
- Protein nutritional support in critically ill patients: pathophysiological basis, clinical evidence, and areas of uncertainty - a narrative review.Frontiers in medicine · 2026Review
- Sleep disorder increases risk of psychiatric disorder in burn survivors.Burns : journal of the International Society for Burn Injuries · 2025Article
- Evaluating the regenerative capacity of biosynthesized nano formulated 3D scaffolds in scald burn healing.RSC advances · 2025Article
- The Metabolic Impact of Biodegradable Temporizing Matrix in Burn Patients: A Retrospective Analysis of Resting Energy Expenditure and Inflammation.Journal of burn care & research : official publication of the American Burn Association · 2025Article
- Hypothyroidism in Severe Burn Patients Associated with Increased Risk of Musculoskeletal Complications and Decreased Risk of Mortality.Journal of burn care & research : official publication of the American Burn Association · 2025Article
- Indirect calorimetry identifies hypermetabolism associated with muscle wasting and increased risk of energy deficit in ICU patients.Critical care (London, England) · 2025Observational
- Early enteral nutrition in critically-ill patients.World journal of critical care medicine · 2025Review
51 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Severe burn injury is followed by a profound hypermetabolic response that persists up to 24 months after injury. It is mediated by up to 50-fold elevations in plasma catecholamines, cortisol, and inflammatory cells that lead to whole-body catabolism, elevated resting energy expenditures, and multiorgan dysfunction. All of these metabolic and physiologic derangements prevent full rehabilitation and acclimatization of burn survivors back into society. Modulation of the response by early excision and grafting of burn wounds, thermoregulation, early and continuous enteral feeding with high-protein high-carbohydrate feedings, and pharmacologic treatments have markedly decreased morbidity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.