ReviewClinical genetics2009
Recent advances of genetic ancestry testing in biomedical research and direct to consumer testing.
Review in Clinical genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Review
- Use of Race in Kidney Function Estimation: Lessons Learned and the Path Toward Health Justice.Annual review of medicine · 2023Review
- Undercutting efforts of precision medicine: roadblocks to minority representation in breast cancer clinical trials.Breast cancer research and treatment · 2021Review
- Impacts of personal DNA ancestry testing.Journal of community genetics · 2021Article
- Direct-to-consumer genetic testing: Prospective users' attitudes toward information about ancestry and biological relationships.PloS one · 2021Article
- Introducing the first whole genomes of nationals from the United Arab Emirates.Scientific reports · 2019Article
- Direct-to-Consumer Genetic Testing's Red Herring: "Genetic Ancestry" and Personalized Medicine.Frontiers in medicine · 2019Article
- Biogeographical ancestry is associated with socioenvironmental conditions and infections in a Latin American urban population.SSM - population health · 2018Article
- Comparison of Genetic and Self-Identified Ancestry in Modeling Intracerebral Hemorrhage Risk.Frontiers in neurology · 2018Article
- Inclusion of diverse populations in genomic research and health services: Genomix workshop report.Journal of community genetics · 2017Article
- Barriers and Strategies Related to Qualitative Research on Genetic Ancestry Testing in Indigenous Communities.Journal of empirical research on human research ethics : JERHRE · 2017Article
- Paternity testing under the cloak of recreational genetics.European journal of human genetics : EJHG · 2017Article
- Genetic polymorphisms of the organic cation transporter 1 gene (SLC22A1) within the Cape Admixed population of South Africa.Molecular biology reports · 2015Article
- Estimates of continental ancestry vary widely among individuals with the same mtDNA haplogroup.American journal of human genetics · 2015Article
- EGFR molecular testing in African-American non-small cell lung cancer patients - a review of discrepant data.Translational lung cancer research · 2013Review
- Genetic ancestry inference using support vector machines, and the active emergence of a unique American population.European journal of human genetics : EJHG · 2013Article
- The use of race, ethnicity and ancestry in human genetic research.The HUGO journal · 2011Article
- Direct-to-consumer personalized genomic testing.Human molecular genetics · 2011Review
- Inferring genetic ancestry: opportunities, challenges, and implications.American journal of human genetics · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
In the post-Human Genome Project era, the debate on the concept of race/ethnicity and its implications for biomedical research are dependent on two critical issues: whether and how to classify individuals and whether biological factors play a role in health disparities. The advent of reliable estimates of genetic (or biogeographic) ancestry has provided this debate with a quantitative and more objective tool. The estimation of genetic ancestry allows investigators to control for population stratification in association studies and helps to detect biological causation behind population-specific differences in disease and drug response. New techniques such as admixture mapping can specifically detect population-specific risk alleles for a disease in admixed populations. However, researchers have to be mindful of the correlation between genetic ancestry and socioeconomic and environmental factors that could underlie these differences. More importantly, researchers must avoid the stigmatization of individuals based on perceived or real genetic risks. The latter point will become increasingly sensitive as several 'for profit companies' are offering ancestry and genetic testing directly to consumers and the consequences of the spread of the services of these companies are still unforeseeable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.