ArticlePharmacotherapy2009
Lack of correlation between thiazide-induced hyperglycemia and hypokalemia: subgroup analysis of results from the pharmacogenomic evaluation of antihypertensive responses (PEAR) study.
Article in Pharmacotherapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00246519 (Pharmacogenomic Evaluation of Antihypertensive Responses), which is not on this map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR)
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Transethnic meta-analysis suggests genetic variation in the HEME pathway influences potassium response in patients treated with hydrochlorothiazide.The pharmacogenomics journal · 2015Pooled it
- Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.The pharmacogenomics journal · 2014Pooled it
- Association of KCNJ1 variation with change in fasting glucose and new onset diabetes during HCTZ treatment.The pharmacogenomics journal · 2013Trial
- Blood pressure responses and metabolic effects of hydrochlorothiazide and atenolol.American journal of hypertension · 2012Trial
- Hypokalemia in Diabetes Mellitus Setting.Medicina (Kaunas, Lithuania) · 2022Review
- Cardiovascular disease and risk of incident diabetes mellitus: Findings from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).Journal of diabetes · 2021Article
- Thiazide Diuretic-Induced Change in Fasting Plasma Glucose: a Meta-analysis of Randomized Clinical Trials.Journal of general internal medicine · 2020Review
- Blood pressure signature genes and blood pressure response to thiazide diuretics: results from the PEAR and PEAR-2 studies.BMC medical genomics · 2018Article
- Whole Transcriptome Sequencing Analyses Reveal Molecular Markers of Blood Pressure Response to Thiazide Diuretics.Scientific reports · 2017Article
- Personalizing the diuretic treatment of hypertension: the need for more clinical and research attention.Current hypertension reports · 2015Review
- Antihypertensive drugs and glucose metabolism.World journal of cardiology · 2014Review
- Does response of RAS blockade on serum K+ levels influence its glycemic-mitigating response when combined with hydrochlorothiazide?Journal of clinical hypertension (Greenwich, Conn.) · 2012Article
- Guidelines for use of diuretics: a view from a member of JNC 7.Journal of clinical hypertension (Greenwich, Conn.) · 2012Article
- Therapeutic options for the treatment of hypertension in children and adolescents.Clinical medicine insights. Circulatory, respiratory and pulmonary medicine · 2012Article
- Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics.Expert review of cardiovascular therapy · 2010Review
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 1 country.
Funding
Abstract
STUDY
objectiveTo determine whether changes in serum glucose, serum potassium, and plasma insulin levels are correlated in a cohort of hypertensive patients.
designPrespecified subgroup analysis of results from a prospective, multicenter, randomized, open-label, parallel-group study. Setting. Primary care clinics at three tertiary care medical centers. PATIENTS: Community-based ambulatory population of 202 patients (age range 17-65 yrs) with a new diagnosis of hypertension, untreated hypertension, or known hypertension, who were previously treated with fewer than three antihypertensive drugs and had no evidence of cardiovascular disease or diabetes mellitus. Intervention. Monotherapy with oral hydrochlorothiazide 12.5 or 25 mg/day for 9 weeks. MEASUREMENTS AND MAIN
resultsFasting serum glucose, serum potassium, and plasma insulin levels were obtained at baseline (before hydrochlorothiazide therapy was started) and after 9 weeks of therapy. Significant elevations were noted in fasting serum glucose (mean +/- SD 3.42 +/- 10.38 mg/dl, p<0.0001) and plasma insulin (2.35 +/- 9.47 microU/ml, p<0.0001) levels, and a significant reduction in serum potassium level (0.30 +/- 0.44 mEq/L, p<0.0001) was noted. No significant correlation was observed between changes in fasting serum glucose and potassium levels (r = 0.022, 95% confidence interval (CI) -0.120-0.164, p=0.757) or between changes in serum potassium and plasma insulin levels (r = -0.112, 95% CI -0.256-0.037, p=0.140). Changes in serum glucose levels did not differ significantly between patients maintaining serum potassium levels of 4.0 mEq/L or greater and those with levels below 4.0 mEq/L.
conclusionChanges in serum potassium and serum glucose levels were not correlated in individuals receiving hydrochlorothiazide monotherapy; thus maintenance of normal potassium levels may not attenuate the risk of thiazide diuretic-induced hyperglycemia.
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Registered trials
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