Evidence map›Paper›PMID 19791771›Full record

ArticleJournal of proteome research2009

Carbohydrate cluster microarrays fabricated on three-dimensional dendrimeric platforms for functional glycomics exploration.

Xichun Zhou, Craig Turchi, Denong Wang

Open access · greenAbstract readEvaluation Study
In one paragraph

Article in Journal of proteome research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
  2. Serum antibody screening using glycan arrays.Chemical Society reviews · 2024
    Review
  3. Glycan Array Technology.Advances in biochemical engineering/biotechnology · 2021
    Article
  4. On-Chip Neo-Glycopeptide Synthesis for Multivalent Glycan Presentation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Carbohydrate microarrays.Chemical Society reviews · 2013
    Review
  11. The 10Journal of proteomics & bioinformatics · 2013
    Article
  12. Article
  13. Carbohydrate antigen microarrays.Methods in molecular biology (Clifton, N.J.) · 2012
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Xichun ZhouADA Technologies, Inc., 8100 Shaffer Parkway, Littleton, Colorado 80127, USA. xichunz@adatech.com
Craig Turchi
Denong Wang
Stanford University · US

Funding

Immunogenic sugar moieties of prostate cancersU01CA128416 · NCI · STANFORD UNIVERSITY · PI WANG, DENONG · 2007 to 2011
$2.3M
Novel 3-dimensional (3-D) platform for high-throughput glycomics analysisR44RR023763 · NCRR · ADA TECHNOLOGIES, INC. · PI ZHANG, JIAN · 2009 to 2011
$1.1M
Novel 3-dimensional platform for high-throughput glycomics discoveryR43RR023763 · NCRR · ADA TECHNOLOGIES, INC. · PI ZHOU, XICHUN · 2007 to 2007
$102k
NCI NIH HHS U01 CA128416NCI NIH HHS U01CA128416NCRR NIH HHS 1R43 RR023763-01NCRR NIH HHS 2R44 RR023763-02NCRR NIH HHS R43 RR023763NCRR NIH HHS R44 RR023763
6 · The paper itself

Abstract

We reported here a novel, ready-to-use bioarray platform and methodology for construction of sensitive carbohydrate cluster microarrays. This technology utilizes a three-dimensional (3-D) poly(amidoamine) starburst dendrimer monolayer assembled on glass surface, which is functionalized with terminal aminooxy and hydrazide groups for site-specific coupling of carbohydrates. A wide range of saccharides, including monosaccharides, oligosaccharides and polysaccharides of diverse structures, are applicable for the 3-D bioarray platform without prior chemical derivatization. The process of carbohydrate coupling is effectively accelerated by microwave radiation energy. The carbohydrate concentration required for microarray fabrication is substantially reduced using this technology. Importantly, this bioarray platform presents sugar chains in defined orientation and cluster configurations. It is, thus, uniquely useful for exploration of the structural and conformational diversities of glyco-epitope and their functional properties.

Indexed as

BuffersCarbohydratesDendrimersGlycomicsMicroarray AnalysisMicrowavesMolecular StructureSurface PropertiesBuffersCarbohydratesDendrimers

Identifiers

PMID19791771
PMCPMC2804876
OpenAlexW2006463471

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.