ArticleProceedings of the National Academy of Sciences of the United States of America1990
Primary structure of keratinocyte transglutaminase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Article
- Type I transglutaminase accumulation in the endoplasmic reticulum may be an underlying cause of autosomal recessive congenital ichthyosis.The Journal of biological chemistry · 2010Article
- Differential alternative splicing of human transglutaminase 4 in benign prostate hyperplasia and prostate cancer.Experimental & molecular medicine · 2010Article
- TIG3: a regulator of type I transglutaminase activity in epidermis.Amino acids · 2009Review
- A three-dimensional model of the human transglutaminase 1: insights into the understanding of lamellar ichthyosis.Journal of molecular modeling · 2007Article
- Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta).Molecular and cellular biology · 2000Article
- Transcription factor Sp1 activates involucrin promoter activity in non-epithelial cell types.The Biochemical journal · 1999Article
- Characterization of human involucrin promoter distal regulatory region transcriptional activator elements-a role for Sp1 and AP1 binding sites.The Biochemical journal · 1998Article
- Defective stratum corneum and early neonatal death in mice lacking the gene for transglutaminase 1 (keratinocyte transglutaminase).Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Inability of keratinocytes lacking their specific transglutaminase to form cross-linked envelopes: absence of envelopes as a simple diagnostic test for lamellar ichthyosis.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Identification of phosphorylation sites in keratinocyte transglutaminase.The Biochemical journal · 1996Article
- Tissue specific and androgen-regulated expression of human prostate-specific transglutaminase.The Biochemical journal · 1996Article
- Tissue transglutaminase and apoptosis: sense and antisense transfection studies with human neuroblastoma cells.Molecular and cellular biology · 1994Article
- Epidermal cancer associated with expression of human papillomavirus type 16 E6 and E7 oncogenes in the skin of transgenic mice.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Cloning and expression of chicken erythrocyte transglutaminase.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Expression of tissue transglutaminase in Balb-C 3T3 fibroblasts: effects on cellular morphology and adhesion.The Journal of cell biology · 1992Article
- Organization and nucleotide sequence of the glutamine synthetase (glnA) gene from Lactobacillus delbrueckii subsp. bulgaricus.Applied and environmental microbiology · 1992Article
- Organization and evolution of the human epidermal keratinocyte transglutaminase I gene.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- New nucleotide sequence data on the EMBL File Server.Nucleic acids research · 1991Article
- New nucleotide sequence data on the EMBL File Server.Nucleic acids research · 1991Article
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Authors and funding
7 authors.
Funding
Abstract
The nucleotide and deduced amino acid sequences of the coding regions of human and rat keratinocyte transglutaminases (protein-glutamine: amine gamma-glutamyltransferase; EC 2.3.2.13) have been determined. These yield proteins of approximately 90 kDa that are 92% identical, indicative of the conservation of important structural features. Alignments of amino acid sequences show substantial similarity among the keratinocyte transglutaminase, human clotting factor XIII catalytic subunit, guinea pig liver tissue transglutaminase, and the human erythrocyte band-4.2 protein. The keratinocyte enzyme is most similar to factor XIII, whereas the band-4.2 protein is most similar to the tissue transglutaminase. A salient feature of the keratinocyte transglutaminase is its 105-residue extension beyond the N terminus of the tissue transglutaminase. This extension and the unrelated activation peptide of factor XIII (a 37-residue extension) appear to be added for specialized functions after divergence of the tissue transglutaminase from their common lineage.
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