ArticleProceedings of the National Academy of Sciences of the United States of America1990
Postsynaptic Hebbian and non-Hebbian long-term potentiation of synaptic efficacy in the entorhinal cortex in slices and in the isolated adult guinea pig brain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Experience-dependent reorganization of inhibitory neuron synaptic connectivity.bioRxiv : the preprint server for biology · 2025Article
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- Direct Electrical Stimulation in Electrocorticographic Brain-Computer Interfaces: Enabling Technologies for Input to Cortex.Frontiers in neuroscience · 2019Review
- A single-cell spiking model for the origin of grid-cell patterns.PLoS computational biology · 2017Article
- Heterosynaptic modulation of evoked synaptic potentials in layer II of the entorhinal cortex by activation of the parasubiculum.Journal of neurophysiology · 2016Article
- An arterially perfused nose-olfactory bulb preparation of the rat.Journal of neurophysiology · 2015Article
- Non-Hebbian long-term potentiation of inhibitory synapses in the thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- A working memory model for serial order that stores information in the intrinsic excitability properties of neurons.Journal of computational neuroscience · 2013Article
- Article
- Intrinsic electrophysiological properties of entorhinal cortex stellate cells and their contribution to grid cell firing fields.Frontiers in neural circuits · 2012Article
- Low-frequency summation of synaptically activated transient receptor potential channel-mediated depolarizations.The European journal of neuroscience · 2011Article
- Non-Hebbian synaptic plasticity induced by repetitive postsynaptic action potentials.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Plasticity of horizontal connections at a functional border in adult rat somatosensory cortex.Neural plasticity · 2009Article
- Receptor for advanced glycation end product-dependent activation of p38 mitogen-activated protein kinase contributes to amyloid-beta-mediated cortical synaptic dysfunction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Postsynaptic signals mediating induction of long-term synaptic depression in the entorhinal cortex.Neural plasticity · 2008Article
- Effect of prenatal protein malnutrition on long-term potentiation and BDNF protein expression in the rat entorhinal cortex after neocortical and hippocampal tetanization.Neural plasticity · 2008Article
- Differential induction of long-term potentiation in the horizontal versus columnar superficial connections to layer II cells of the entorhinal cortex.Neural plasticity · 2008Article
- The role of NMDA receptor subtypes in short-term plasticity in the rat entorhinal cortex.Neural plasticity · 2008Article
- HCN1 channels control resting and active integrative properties of stellate cells from layer II of the entorhinal cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Bidirectional activity-dependent plasticity at corticostriatal synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
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3 authors.
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Abstract
Long-term potentiation (LTP) was investigated in the mammalian entorhinal cortex by using two in vitro preparations, the isolated brain and the entorhinal cortex slice. Hebbian and non-Hebbian types of LTP appear to be present in layer II entorhinal cortex cells as demonstrated using two protocols: (i) tetanic stimulation of the piriform-entorhinal cortex afferent pathway to generate homosynaptic potentiation and (ii) postsynaptic subthreshold rhythmic membrane potential manipulation not paired to presynaptic activation, which gives rise to non-Hebbian LTP. The induction and the expression of both types of LTP were found to be dependent on activation of N-methyl-D-aspartate receptors as shown by their sensitivity to the receptor agonist D-2-amino-5-phosphonovalerate. This is in contrast to LTP in the hippocampus [Zalutsky, R. A. & Nicoll, R. A. (1990) Science 248, 1619-1624], where LTP is expressed by quisqualate receptors. Since, in the entorhinal cortex, LTP is linked to a selective increase of the N-methyl-D-aspartate-receptor-mediated synaptic responses, this enhancement is most likely due to postsynaptic factors.
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