ArticleProceedings of the National Academy of Sciences of the United States of America1990
Tissue-specific transformation by epidermal growth factor receptor: a single point mutation within the ATP-binding pocket of the erbB product increases its intrinsic kinase activity and activates its sarcomagenic potential.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- The structural impact of cancer-associated missense mutations in oncogenes and tumor suppressors.Molecular cancer · 2011Article
- (124)I-iodopyridopyrimidinone for PET of Abl kinase-expressing tumors in vivo.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2010Article
- Wa5 is a novel ENU-induced antimorphic allele of the epidermal growth factor receptor.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- Characterization of an activated mutant of focal adhesion kinase: 'SuperFAK'.The Biochemical journal · 2002Article
- Article
- Tyrosine kinase inhibitors in preclinical development.Investigational new drugs · 1999Review
- Enhanced signaling and morphological transformation by a membrane-localized derivative of the fibroblast growth factor receptor 3 kinase domain.Molecular and cellular biology · 1997Article
- Constitutive activation of the RON gene promotes invasive growth but not transformation.Molecular and cellular biology · 1996Article
- The v-erbB oncogene confers enhanced cellular susceptibility to reovirus infection.Journal of virology · 1996Article
- Disease specificity of kinase domains: the src-encoded catalytic domain converts erbB into a sarcoma oncogene.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- A minor tyrosine phosphorylation site located within the CAIN domain plays a critical role in regulating tissue-specific transformation by erbB kinase.Journal of virology · 1995Article
- Modulation of erbB kinase activity and oncogenic potential by single point mutations in the glycine loop of the catalytic domain.Molecular and cellular biology · 1994Article
- Analysis of the role of the Shc and Grb2 proteins in signal transduction by the v-ErbB protein.Molecular and cellular biology · 1994Article
- Induction of renal adenocarcinoma by a nonmutated erbB oncogene.Journal of virology · 1993Article
- Transforming properties and substrate specificities of the protein tyrosine kinase oncogenes ros and src and their recombinants.Journal of virology · 1992Article
- Protein tyrosine kinase activities of the epidermal growth factor receptor and ErbB proteins: correlation of oncogenic activation with altered kinetics.Molecular and cellular biology · 1992Article
- Dissecting the activating mutations in v-erbB of avian erythroblastosis virus strain R.Journal of virology · 1991Article
- The amino-terminal 14 amino acids of v-src can functionally replace the extracellular and transmembrane domains of v-erbB.Molecular and cellular biology · 1991Article
- Growth factors and tyrosine protein kinases in normal and malignant melanocytes.Cancer metastasis reviews · 1991Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Avian c-erbB is activated to a leukemia oncogene following truncation of its amino-terminal, ligand-binding domain by retroviral insertion. The insertionally activated transcripts encode protein products that have constitutive tyrosine kinase activity and that can induce erythro-leukemia but not sarcomas. We have found that a single point mutation within the ATP-binding pocket of the tyrosine kinase domain in this truncated molecule can increase the ability of this oncogene to induce anchorage-independent growth of fibroblasts in vitro and fibrosarcoma formation in vivo. Associated with this increased transforming potential is a corresponding increase in the kinase activity of the mutant erbB protein product. The mutation, which converts a valine to isoleucine at position 157 of the insertionally activated c-erbB product, is at a residue that is highly conserved within the protein kinase family. To our knowledge, this is the first demonstration of a point mutation in the ATP-binding pocket that activates a tyrosine kinase.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.