ArticleHippocampus2010
Aging alters the expression of genes for neuroprotection and synaptic function following acute estradiol treatment.
Article in Hippocampus, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 42 citations in OpenAlex.
- Sex, senescence, senolytics, and cognition.Frontiers in aging neuroscience · 2025Review
- Influence of age and sex on microRNA response and recovery in the hippocampus following sepsis.Aging · 2022Article
- Sex Differences in the Role of Neurexin 3α in Zoster Associated Pain.Frontiers in integrative neuroscience · 2022Article
- Neutrophil dynamics and inflammaging in acute ischemic stroke: A transcriptomic review.Frontiers in aging neuroscience · 2022Review
- Adulthood systemic inflammation accelerates the trajectory of age-related cognitive decline.Aging · 2021Article
- Estrogen receptor involvement in vascular cognitive impairment and vascular dementia pathogenesis and treatment.GeroScience · 2021Review
- Examination of CA1 Hippocampal DNA Methylation as a Mechanism for Closing of Estrogen's Critical Window.Frontiers in aging neuroscience · 2021Article
- Oestradiol as a neuromodulator of learning and memory.Nature reviews. Neuroscience · 2020Review
- Hippocampal Subregion Transcriptomic Profiles Reflect Strategy Selection during Cognitive Aging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- G Protein-Coupled Estrogen Receptor: Rapid Effects on Hippocampal-Dependent Spatial Memory and Synaptic Plasticity.Frontiers in endocrinology · 2020Article
- Aging Reduces Estradiol Protection Against Neural but Not Metabolic Effects of Obesity in Female 3xTg-AD Mice.Frontiers in aging neuroscience · 2020Article
- Ginsenoside Rg1 ameliorates the cognitive deficits in D-galactose and AlClInternational journal of medical sciences · 2020Article
- Age and Sex Influence the Hippocampal Response and Recovery Following Sepsis.Molecular neurobiology · 2019Article
- Mechanisms underlying the rapid effects of estradiol and progesterone on hippocampal memory consolidation in female rodents.Hormones and behavior · 2018Review
- Transcription Profile of Aging and Cognition-Related Genes in the Medial Prefrontal Cortex.Frontiers in aging neuroscience · 2016Article
- Re-Opening the Critical Window for Estrogen Therapy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Contribution of estrogen receptor subtypes, ERα, ERβ, and GPER1 in rapid estradiol-mediated enhancement of hippocampal synaptic transmission in mice.Hippocampus · 2015Article
- Contribution of N-methyl-D-aspartate receptors to attention and episodic spatial memory during senescence.Neurobiology of learning and memory · 2015Article
- Molecular mechanisms underlying the memory-enhancing effects of estradiol.Hormones and behavior · 2015Review
- Gene expression profiling in the hippocampus of orchidectomized rats.Journal of molecular neuroscience : MN · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
This study used microarray analysis to examine age-related changes in gene expression 6 and 12 h following a single estradiol injection in ovariectomized mice. Estradiol-responsive gene expression at the 6 h time point was reduced in aged (18 months) animals compared with young (4 months) and middle-aged (MA, 12 months) mice. Examination of gene clustering within biological and functional pathways indicated that young and MA mice exhibited increased expression of genes for cellular components of the synapse and decreased expression of genes related to oxidative phosphorylation and mitochondrial dysfunction. At the 12 h time point, estradiol-responsive gene expression increased in aged animals and decreased in young and MA mice compared with the 6 h time point. Gene clustering analysis indicated that aged mice exhibited increased expression of genes for signaling pathways that are rapidly influenced by estradiol. The age differences in gene expression for rapid signaling pathways may relate to disparity in basal pathway activity and estradiol mediated activation of rapid signaling cascades.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.