SynthesisArthritis and rheumatism2009
HLA-B51/B5 and the risk of Behçet's disease: a systematic review and meta-analysis of case-control genetic association studies.
Synthesis in Arthritis and rheumatism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 180 papers, 9 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
180 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- Association of the Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism with Increased Susceptibility to Vasculitis: A Systematic Review and Meta-Analysis.Mediterranean journal of rheumatology · 2026Pooled it
- Epidemiology and clinical features of Behçet's disease in the Middle East and North Africa:A systematic review and meta-analysis.Clinical rheumatology · 2026Pooled it
- Behçet's Disease In Children And Adults Of Sub-Saharan Ancestry: A Systematic Review And Meta-Analysis.Clinical reviews in allergy & immunology · 2025Pooled it
- Behçet's Disease: A Comprehensive Review on the Role ofInternational journal of molecular sciences · 2023Pooled it
- Sex-specific analysis in Behçet's disease reveals higher genetic risk in male patients.Journal of autoimmunity · 2022Pooled it
- Global Meta-Analysis on the Association between Behcet Syndrome and Polymorphisms from the HLA Class I (A, B, and C) and Class II (DRB1, DQB1, and DPB1) Genes.Disease markers · 2021Pooled it
- Association of HLA-DR4/HLA-DRB1*04 with Vogt-Koyanagi-Harada disease: a systematic review and meta-analysis.Scientific reports · 2014Pooled it
- Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.Nature genetics · 2013Pooled it
- Polymorphisms in the tumor necrosis factor gene and susceptibility to Behcet's disease: an updated meta-analysis.Molecular vision · 2013Pooled it
- The expression and methylation status of vitamin D receptor gene in Behcet's disease.Immunity, inflammation and disease · 2019Trial
- Oral aphthosis in children: baseline clinical features associated with diagnostic categories in a single-centre retrospective cohort.European journal of pediatrics · 2026Article
- Diabetes Mellitus Prevalence by Uveitis Etiology at a Japanese Tertiary Center.Diagnostics (Basel, Switzerland) · 2026Article
- A Complex Case of Behçet's Disease With Severe Genital Ulceration: Diagnostic Challenges.Cureus · 2026Article
- Adult patients with autoinflammation of unknown origin partially phenocopy the immune presentation of Still's disease.Nature communications · 2026Article
- Behçet's Syndrome.Current rheumatology reports · 2026Review
- Biological therapies in paediatric Behçet's disease: results of an international collaborative study by the PRES Vasculitis Working Party.Rheumatology (Oxford, England) · 2026Article
- Retinal thickness and microvascular alterations in the diagnosis of behcet's disease: a case-control study.BMC medical imaging · 2026Article
- Behçet's disease and avascular necrosis of the knees: a case report.Annals of medicine and surgery (2012) · 2026Article
- PDE4 inhibitor mitigates activated CD8+ T cells through NF-κB signaling in Behçet's syndrome.Frontiers in immunology · 2026Article
- Genetic analysis of Behçet's disease using whole-exome sequencing and bioinformatics analysis in Korean patients.Frontiers in genetics · 2026Article
120 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectiveTo quantify by meta-analysis the genetic effect of the HLA-B5 or HLA-B51 (HLA-B51/B5) allele on the risk of developing Behçet's disease (BD) and to look for potential effect modifiers.
methodsRelevant studies were identified using the PubMed Medline database and manual searches of the literature. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated by using the random-effects model. Subgroup meta-analyses and meta-regression analyses were undertaken to investigate the effects of selected study-level parameters on the pooled OR. Heterogeneity was assessed using the I2 statistic. Pooled results were used to calculate population-attributable risks (PAR) for BD in relationship to HLA-B51/B5.
resultsA total of 4,800 patients with BD and 16,289 controls from 78 independent studies (published 1975-2007) were selected. The pooled OR of HLA-B51/B5 allele carriers to develop BD compared with noncarriers was 5.78 (95% CI 5.00-6.67), with moderate between-study heterogeneity (I2 = 61%). The subgroup analyses stratifying studies by geographic locations (Eastern Asia, Middle East/North Africa, Southern Europe, Northern/Eastern Europe) yielded consistent OR ranges (5.31-7.20), with I2 ranges of 52-70%. Univariate random-effects meta-regression indicated the percentage of male BD cases (P = 0.008) as a source of heterogeneity. The PAR within the various geographic areas were estimated at 32-52%.
conclusionThe strength of the association between BD and HLA-B51/B5, and its consistency across populations of various ethnicities, lends further support to this allele being a primary and causal risk determinant for BD. Variations according to sex support an interaction of this allele with BD characteristics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.