ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2009
Physical mapping of the elephant X chromosome: conservation of gene order over 105 million years.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 66 citations in OpenAlex.
- Comparative Genomics Reveals the Ancestral Recombination Landscape of Placental Mammals.bioRxiv : the preprint server for biology · 2026Article
- Chromosome-level genome assembly of the common tenrec, Tenrec ecaudatus (Schreber, 1778), a new model for early placental mammal evolution.BMC genomics · 2026Article
- Compensation of gene dosage on the mammalian X.Development (Cambridge, England) · 2024Review
- Sirenian genomes illuminate the evolution of fully aquatic species within the mammalian superorder afrotheria.Nature communications · 2024Article
- Hi-C scaffolded short- and long-read genome assemblies of the California sea lion are broadly consistent for syntenic inference across 45 million years of evolution.Molecular ecology resources · 2021Article
- Genomic architecture constrained placental mammal X Chromosome evolution.Genome research · 2021Article
- The Diversity of Plant Sex Chromosomes Highlighted through Advances in Genome Sequencing.Genes · 2021Review
- X-Linked Signature of Reproductive Isolation in Humans is Mirrored in a Howler Monkey Hybrid Zone.The Journal of heredity · 2020Article
- X chromosome variants are associated with male fertility traits in two bovine populations.Genetics, selection, evolution : GSE · 2020Article
- Recombination-Aware Phylogenomics Reveals the Structured Genomic Landscape of Hybridizing Cat Species.Molecular biology and evolution · 2019Article
- Multiple forms of selection shape reproductive isolation in a primate hybrid zone.Molecular ecology · 2019Article
- Chromosome Evolution in Marsupials.Genes · 2018Review
- Novel and divergent genes in the evolution of placental mammals.Proceedings. Biological sciences · 2017Article
- Male Mutation Bias Is the Main Force Shaping Chromosomal Substitution Rates in Monotreme Mammals.Genome biology and evolution · 2017Article
- X Chromosome Evolution in Cetartiodactyla.Genes · 2017Article
- Y chromosome palindromes and gene conversion.Human genetics · 2017Review
- Did sex chromosome turnover promote divergence of the major mammal groups?: De novo sex chromosomes and drastic rearrangements may have posed reproductive barriers between monotremes, marsupials and placental mammals.BioEssays : news and reviews in molecular, cellular and developmental biology · 2016Review
- Article
- Rapid evolutionary turnover underlies conserved lncRNA-genome interactions.Genes & development · 2016Article
- Weird mammals provide insights into the evolution of mammalian sex chromosomes and dosage compensation.Journal of genetics · 2015Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
All therian mammals (eutherians and marsupials) have an XX female/XY male sex chromosome system or some variant of it. The X and Y evolved from a homologous pair of autosomes over the 166 million years since therian mammals diverged from monotremes. Comparing the sex chromosomes of eutherians and marsupials defined an ancient X conserved region that is shared between species of these mammalian clades. However, the eutherian X (and the Y) was augmented by a recent addition (XAR) that is autosomal in marsupials. XAR is part of the X in primates, rodents, and artiodactyls (which belong to the eutherian clade Boreoeutheria), but it is uncertain whether XAR is part of the X chromosome in more distantly related eutherian mammals. Here we report on the gene content and order on the X of the elephant (Loxodonta africana)-a representative of Afrotheria, a basal endemic clade of African mammals-and compare these findings to those of other documented eutherian species. A total of 17 genes were mapped to the elephant X chromosome. Our results support the hypothesis that the eutherian X and Y chromosomes were augmented by the addition of autosomal material prior to eutherian radiation. Not only does the elephant X bear the same suite of genes as other eutherian X chromosomes, but gene order appears to have been maintained across 105 million years of evolution, perhaps reflecting strong constraints posed by the eutherian X inactivation system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.