ArticleJournal of clinical immunology2010
Contribution of cyclophilin A to the regulation of inflammatory processes in rheumatoid arthritis.
Article in Journal of clinical immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 55 citations in OpenAlex.
- Extracellular cyclophilin A promotes B-cell acute lymphoblastic leukemia progression via MC2R.EMBO molecular medicine · 2026Article
- Review
- Secreted Extracellular Cyclophilin A Is a Novel Mediator of Ventilator-induced Lung Injury.American journal of respiratory and critical care medicine · 2021Article
- Article
- Diagnostic Performance of Cyclophilin A in Cardiac Surgery-Associated Acute Kidney Injury.Journal of clinical medicine · 2019Article
- Inhibition of Cyclophilin A on the replication of red spotted grouper nervous necrosis virus associates with multiple pro-inflammatory factors.Fish & shellfish immunology · 2019Article
- Article
- Cyclophilin a increases CD68Journal of molecular histology · 2018Article
- CD147-mediated chemotaxis of CD4Clinical rheumatology · 2018Article
- The clinical implication of serum cyclophilin A in patients with chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2018Article
- Cyclophilin A Aggravates Collagen-Induced Arthritis via Promoting Classically Activated Macrophages.Inflammation · 2017Article
- Serum Cyclophilin A Correlates with Increased Tissue MMP-9 in Patients with Ulcerative Colitis, but Not with Crohn's Disease.Digestive diseases and sciences · 2017Article
- Extracellular cyclophilins in health and disease.Biochimica et biophysica acta · 2015Review
- Cyclophilin A: a key player for human disease.Cell death & disease · 2013Review
- Inhibition of synovitis and joint destruction by a new single domain antibody specific for cyclophilin A in two different mouse models of rheumatoid arthritis.Arthritis research & therapy · 2013Article
- Functions of cyclophilin A in atherosclerosis.Experimental and clinical cardiology · 2013Article
- Cyclophilin A secreted from fibroblast-like synoviocytes is involved in the induction of CD147 expression in macrophages of mice with collagen-induced arthritis.Journal of inflammation (London, England) · 2012Article
- HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease.Nature reviews. Rheumatology · 2012Review
- Disrupting the EMMPRIN (CD147)-cyclophilin A interaction reduces infarct size and preserves systolic function after myocardial ischemia and reperfusion.Arteriosclerosis, thrombosis, and vascular biology · 2011Article
- Cyclophilin A: promising new target in cardiovascular therapy.Circulation journal : official journal of the Japanese Circulation Society · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPrevious studies show that cyclophilin A (CypA) acts as a strong chemotactic cytokine to neutrophils, eosinophils, and monocytes in rheumatoid arthritis (RA).
methodsIn this study, monocytes were stimulated by purified CypA and the production of matrix metalloproteinase (MMPs), the cell invasion and the release of inflammatory cytokines were detected respectively by gelatin zymography, invasion assay, and cytometric bead array FCM.
resultsThe elevated level of inflammatory cytokine IL-8 was also detected. Results showed that CypA significantly promoted the invasion of THP-1 cells and increased the production of MMP-2 and MMP-9, which displayed a biphasic concentration dependency. In vivo experiments found that the cartilage erosion scores in CypA injection group were significantly higher than those in control group (P < 0.05).
conclusionOur findings suggest that CypA significantly enhances the secretion of MMP-2 and MMP-9, the cell invasion, and the inflammatory cytokines production of monocytes. Our findings may shed some new light on the inflammatory process and the degradation of cartilage and bone in RA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.