ArticlePhysiological genomics2009
Quantitative trait loci for exercise training responses in FVB/NJ and C57BL/6J mice.
Article in Physiological genomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Article
- Article
- Mitochondrial DNA lesions and copy number are strain dependent in endurance-trained mice.Physiological reports · 2020Article
- Precision exercise medicine: understanding exercise response variability.British journal of sports medicine · 2019Article
- Contribution of Chromosome 14 to Exercise Capacity and Training Responses in Mice.Frontiers in physiology · 2019Article
- Inter-individual variation in adaptations to endurance and resistance exercise training: genetic approaches towards understanding a complex phenotype.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Differences in Exercise Capacity and Responses to Training in 24 Inbred Mouse Strains.Frontiers in physiology · 2017Article
- Forced Running Endurance Is Influenced by Gene(s) on Mouse Chromosome 10.Frontiers in physiology · 2017Article
- Article
- Effect of chromosome substitution on intrinsic exercise capacity in mice.F1000Research · 2014Article
- Identification of exercise capacity QTL using association mapping in inbred mice.Physiological genomics · 2012Article
- Genetic dissection of testis weight in mice: quantitative trait locus analysis using F(2) intercrosses between strains with extreme testis weight, and association study using Y-consomic strains.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
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Authors and funding
3 authors.
Funding
Abstract
The genetic factors determining the magnitude of the response to exercise training are poorly understood. The aim of this study was to identify quantitative trait loci (QTL) associated with adaptation to exercise training in a cross between FVB/NJ (FVB) and C57BL/6J (B6) mice. Mice completed an exercise performance test before and after a 4-wk treadmill running program, and changes in exercise capacity, expressed as work (kg.m), were calculated. Changes in work in F(2) mice averaged 1.51 +/- 0.08 kg.m (94.3 +/- 7.3%), with a range of -1.67 to +4.55 kg.m. All F(2) mice (n = 188) were genotyped at 20-cM intervals with 103 single nucleotide polymorphisms (SNPs), and genomewide linkage scans were performed for pretraining, posttraining, and change in work. Significant QTL for pretraining work were located on chromosomes 14 at 4.0 cM [3.72 logarithm of odds (LOD)] and 19 at 34.4 cM (3.63 LOD). For posttraining work significant QTL were located on chromosomes 3 at 60 cM (4.66 LOD) and 14 at 26 cM (4.99 LOD). Suggestive QTL for changes in work were found on chromosomes 11 at 44.6 cM (2.30 LOD) and 14 at 36 cM (2.25 LOD). When pretraining work was used as a covariate, a potential QTL for change in work was identified on chromosome 6 at 68 cM (3.56 LOD). These data indicate that one or more QTL determine exercise capacity and training responses in mice. Furthermore, these data suggest that the genes that determine pretraining work and training responses may differ.
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