ArticleThe Plant cell2009
MAP kinase phosphatase1 and protein tyrosine phosphatase1 are repressors of salicylic acid synthesis and SNC1-mediated responses in Arabidopsis.
Article in The Plant cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers.
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Who cites it
111 citing papers in PubMed, 225 citations in OpenAlex.
- From signals to solutions: stress-induced leaf senescence and synthetic biology and AI approaches for crop resilience.Molecular horticulture · 2026Review
- Genetic analyses of autoimmune mutants uncover the MPK3/6-CHR5-SNC1 module in Arabidopsis.Scientific reports · 2026Article
- HDA6 represses the histone acetylation modification and expression of WRKY18/40 to inhibit camalexin biosynthesis in Arabidopsis.Plant cell reports · 2026Article
- Dimerization-activated PP2C-D2 and D5 phosphatases negatively regulate brassinosteroid signaling by antagonizing BRI1.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Abscission zones: cellular interfaces for the programmed separation of organs.Annals of botany · 2025Review
- Genome-wide association studies dissect the genetic architecture of seed and yield component traits in cowpea (Vigna unguiculata L. Walp).G3 (Bethesda, Md.) · 2025Article
- A viral protein activates the MAPK pathway to promote viral infection by downregulating callose deposition in plants.Nature communications · 2024Article
- The pan-NLRome analysis based on 23 genomes reveals the diversity of NLRs inMolecular breeding : new strategies in plant improvement · 2024Article
- Emerging Functions of Protein Tyrosine Phosphatases in Plants.International journal of molecular sciences · 2024Review
- Article
- Transporter-mediated depletion of extracellular proline directly contributes to plant pattern-triggered immunity against a bacterial pathogen.Nature communications · 2024Article
- CRISPR-targeted mutagenesis of mitogen-activated protein kinase phosphatase 1 improves both immunity and yield in wheat.Plant biotechnology journal · 2024Article
- Insights into the early transcriptomic response against watermelon mosaic virus in melon.BMC plant biology · 2024Article
- Morphological and transcriptional analysis of Colletotrichum lindemuthianum race 7 during early stages of infection in common bean.Genetics and molecular biology · 2024Article
- Mitogen-activated protein kinase phosphatase 1 controls broad spectrum disease resistance inFrontiers in plant science · 2024Article
- A necessary considering factor for breeding: growth-defense tradeoff in plants.Stress biology · 2023Review
- Potato protein tyrosine phosphatase StPTP1a is activated by StMKK1 to negatively regulate plant immunity.Plant biotechnology journal · 2023Article
- Exogenous application of salicylic acid improves freezing stress tolerance in alfalfa.Frontiers in plant science · 2023Article
- Plant responses to UV-B radiation: signaling, acclimation and stress tolerance.Stress biology · 2022Review
- Compartmentalization, a key mechanism controlling the multitasking role of the SnRK1 complex.Journal of experimental botany · 2022Review
51 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitogen-activated protein (MAP) kinase phosphatases are important negative regulators of the levels and kinetics of MAP kinase activation that modulate cellular responses. The dual-specificity phosphatase MAP KINASE PHOSPHATASE1 (MKP1) was previously shown to regulate MAP KINASE6 (MPK6) activation levels and abiotic stress responses in Arabidopsis thaliana. Here, we report that the mkp1 null mutation in the Columbia (Col) accession results in growth defects and constitutive biotic defense responses, including elevated levels of salicylic acid, camalexin, PR gene expression, and resistance to the bacterial pathogen Pseudomonas syringae. PROTEIN TYROSINE PHOSPHATASE1 (PTP1) also interacts with MPK6, but the ptp1 null mutant shows no aberrant growth phenotype. However, the pronounced constitutive defense response of the mkp1 ptp1 double mutant reveals that MKP1 and PTP1 repress defense responses in a coordinated fashion. Moreover, mutations in MPK3 and MPK6 distinctly suppress mkp1 and mkp1 ptp1 phenotypes, indicating that MKP1 and PTP1 act as repressors of inappropriate MPK3/MPK6-dependent stress signaling. Finally, we provide evidence that the natural modifier of mkp1 in Col is largely the disease resistance gene homolog SUPPRESSOR OF npr1-1, CONSTITUTIVE 1 (SNC1) that is absent in the Wassilewskija accession. Our data thus indicate a major role of MKP1 and PTP1 in repressing salicylic acid biosynthesis in the autoimmune-like response caused by SNC1.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.