ArticleEvidence-based complementary and alternative medicine : eCAM2011
Protective Effects of Rosa damascena and Its Active Constituent on Aβ(25-35)-Induced Neuritic Atrophy.
Article in Evidence-based complementary and alternative medicine : eCAM, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
- Effects of Rosa damascena and its compounds on smooth muscle contractility.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2026Review
- A comprehensive assessment of the cholinergic-supporting and cognitive-enhancing effects of Rosa damascena Mill. (Damask rose) essential oil on scopolamine-induced amnestic rats.Brain and behavior · 2024Article
- Oxidative Stress Mediated Cytotoxicity, Cell Cycle Arrest, and Apoptosis Induced byOxidative medicine and cellular longevity · 2021Article
- 1,25(OH)International journal of molecular sciences · 2020Article
- Novel Effects ofInternational journal of preventive medicine · 2018Article
- Rosa damascena as holy ancient herb with novel applications.Journal of traditional and complementary medicine · 2016Review
- Neuroprotective effects of Rosa damascena extract on learning and memory in a rat model of amyloid-β-induced Alzheimer's disease.Advanced biomedical research · 2015Article
- Amyloid-beta: a crucial factor in Alzheimer's disease.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2015Review
- Rosa damascena oil improves SSRI-induced sexual dysfunction in male patients suffering from major depressive disorders: results from a double-blind, randomized, and placebo-controlled clinical trial.Neuropsychiatric disease and treatment · 2015Article
- Nutraceuticals for geriatrics.Journal of traditional and complementary medicine · 2015Review
- Extension of Drosophila lifespan by Rosa damascena associated with an increased sensitivity to heat.Biogerontology · 2012Article
- Nutraceutical interventions for promoting healthy aging in invertebrate models.Oxidative medicine and cellular longevity · 2012Review
- Pharmacological effects of rosa damascena.Iranian journal of basic medical sciences · 2011Article
- Anticonvulsant and neuroprotective effects of Rosa damascena hydro-alcoholic extract on rat hippocampus.Avicenna journal of phytomedicineArticle
Corrections and comments
- Retraction · 2011-09-07Concerns/Issues about Data · Unreliable Data · Unreliable Results and/or Conclusions ·
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dementia is a clinical syndrome characterized by multiple cognitive deficits and causes progressive neurodegeneration leading eventually to death. The incidence of dementia is increasing worldwide with the increase in ageing population. However, no effective treatment is available yet. It has been hypothesized that drugs activating neurite outgrowth might induce neuronal reconstruction and help in the recovery of brain function. Working on this hypothesis, we recently observed that the chloroform extract of the Rosa damascena significantly induced the neurite outgrowth activity and inhibited the Aβ(25-35)-induced atrophy and cell death. Further workup led the isolation of a very long polyunsaturated fatty acid having molecular formula C(37)H(64)O(2) as an active constituent. The structure of this compound was established by extensive analysis of fragmentations observed in EI-MS mode. The isolated compound protected Aβ(25-35)-induced atrophy and displayed strong neurite outgrowth activity. The length of dendrite in the cells treated with this compound were comparable to those of nerve growth factor (NGF) treated cells.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.