ArticleEmerging infectious diseases2009
Predicting phenotype and emerging strains among Chlamydia trachomatis infections.
Article in Emerging infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 94 citations in OpenAlex.
- A cohort study of Chlamydia trachomatis treatment failure in women: a study protocol.BMC infectious diseases · 2013Trial
- A new core-genome MLST approach for Chlamydia trachomatis genomic surveillance and research.Nature communications · 2026Article
- A Nationwide Investigation on the Distribution and Antimicrobial Susceptibility Profiling ofInfection & chemotherapy · 2026Article
- Whole-genome automated assembly pipeline forNAR genomics and bioinformatics · 2025Article
- Unravelling Chlamydia trachomatis diversity in Amhara, Ethiopia: MLVA-ompA sequencing as a molecular typing tool for trachoma.PLoS neglected tropical diseases · 2024Article
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- Whole Genome Sequencing of aCurrent issues in molecular biology · 2023Article
- Emergence of NovelMicroorganisms · 2022Article
- Specific high-resolution scheme to improve understanding of the spatio-temporal dispersion of lymphogranuloma venereum epidemic.Frontiers in microbiology · 2022Article
- Use of real-time PCR as an alternative to conventional genotyping methods for the laboratory detection of lymphogranuloma venereum (LGV).Diagnostic microbiology and infectious disease · 2021Article
- Ongoing evolution ofMicrobial genomics · 2021Article
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- Whole-Genome Enrichment and Sequencing of Chlamydia trachomatis Directly from Patient Clinical Vaginal and Rectal Swabs.mSphere · 2021Article
- High-resolution multilocus sequence typing for Chlamydia trachomatis: improved results for clinical samples with low amounts of C. trachomatis DNA.BMC microbiology · 2021Article
- Chlamydia trachomatis isolated from cervicovaginal samples in Sapporo, Japan, reveals the circulation of genetically diverse strains.BMC infectious diseases · 2020Article
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- An Asymptomatic Patient with Fatal Infertility Carried a Swedish Strain ofMicroorganisms · 2019Article
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- Genomic analyses of the Chlamydia trachomatis core genome show an association between chromosomal genome, plasmid type and disease.BMC genomics · 2018Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Chlamydia trachomatis is a global cause of blinding trachoma and sexually transmitted infections (STIs). We used comparative genomics of the family Chlamydiaceae to select conserved housekeeping genes for C. trachomatis multilocus sequencing, characterizing 19 reference and 68 clinical isolates from 6 continental/subcontinental regions. There were 44 sequence types (ST). Identical STs for STI isolates were recovered from different regions, whereas STs for trachoma isolates were restricted by continent. Twenty-nine of 52 alleles had nonuniform distributions of frequencies across regions (p<0.001). Phylogenetic analysis showed 3 disease clusters: invasive lymphogranuloma venereum strains, globally prevalent noninvasive STI strains (ompA genotypes D/Da, E, and F), and nonprevalent STI strains with a trachoma subcluster. Recombinant strains were observed among STI clusters. Single nucleotide polymorphisms (SNPs) were predictive of disease specificity. Multilocus and SNP typing can now be used to detect diverse and emerging C. trachomatis strains for epidemiologic and evolutionary studies of trachoma and STI populations worldwide.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.