ReviewAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology2009
The role of viruses in the development and exacerbation of atopic disease.
Review in Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Trial
- The enteric DNA virome differs in infants at risk for atopic disease.Gut microbes · 2026Article
- Type I IFN-dependent FcγRIV signaling in murine monocytes promotes lethal anaphylaxis during viral infections.The Journal of clinical investigation · 2026Article
- Association between early viral lower respiratory tract infections and subsequent asthma development.World journal of critical care medicine · 2022Article
- Atopic Neutrophils Prevent Postviral Airway Disease.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Viruses and asthma: the role of common respiratory viruses in asthma and its potential meaning for SARS-CoV-2.Immunology · 2020Review
- Asthma and viral infections: An intricate relationship.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2019Review
- The human viral challenge model: accelerating the evaluation of respiratory antivirals, vaccines and novel diagnostics.Respiratory research · 2018Review
- Economic burden of diagnosed pertussis among individuals with asthma or chronic obstructive pulmonary disease in the USA: an analysis of administrative claims.Epidemiology and infection · 2017Article
- Structure-function analysis of CCL28 in the development of post-viral asthma.The Journal of biological chemistry · 2015Article
- Natural killer cells in asthma.Frontiers in immunology · 2013Article
- Role of viruses in the development of atopic disease in pediatric patients.Current allergy and asthma reports · 2012Review
- The effect of single and multiple infections on atopy and wheezing in children.The Journal of allergy and clinical immunology · 2012Article
- Dendritic cells, viruses, and the development of atopic disease.Journal of allergy · 2012Article
- Development of atopy by severe paramyxoviral infection in a mouse model.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2010Article
- Immune response to varicella vaccine in children with atopic dermatitis compared with nonatopic controls.The Journal of allergy and clinical immunology · 2010Article
- Awareness and Current Therapeutics of Asthma.Dose-response : a publication of International Hormesis SocietyReview
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine data in support of the viral hypothesis of atopic disease. DATA SOURCES: We retrieved review articles and original research from MEDLINE, OVID, and PubMed (1950-June 2009) that addressed our topic of interest, using the terms respiratory virus, asthma, IgE, atopy, and viral-induced wheeze. STUDY SELECTION: Articles were selected for their relevance to viruses and their role in asthma.
resultsMuch of the data in support of the viral role in asthma focuses on rhinovirus and respiratory syncytial virus. Epidemiologic studies have used factors such as day-care and family size as surrogates for infection in studies that support and negate the role of viruses in the development of asthma. A large volume of literature supports the theory that virus exacerbates preexisting asthma by setting off the inflammatory cascade. No mechanistic studies fully explain how viral infections can translate or exacerbate atopic disease. We provide information from our mouse model that suggests that dendritic cells, IgE, and FcepsilonRI are critical to the induction of atopy. Studies of patients taking antiviral agents (e.g., ribavirin or palvizumab) support the notion that interfering with respiratory viral infections may decrease the development of atopy.
conclusionsMany studies suggest strongly that viral infections may predispose patients to the development of asthma and other atopic diseases. Further, mechanistic studies are necessary to allow for the development of targeted therapeutics to prevent the translation of viral into atopic disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.