ArticleHead & neck2010
Hyperphosphorylation of replication protein A in cisplatin-resistant and -sensitive head and neck squamous cell carcinoma cell lines.
Article in Head & neck, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- TTK activates ATR through RPA2 phosphorylation to promote olaparib resistance in ovarian cancer.Communications biology · 2025Article
- CRL4 ubiquitin ligase stimulates Fanconi anemia pathway-induced single-stranded DNA-RPA signaling.BMC cancer · 2019Article
- Phosphatase 1 Nuclear Targeting Subunit Mediates Recruitment and Function of Poly (ADP-Ribose) Polymerase 1 in DNA Repair.Cancer research · 2019Article
- S4S8-RPA phosphorylation as an indicator of cancer progression in oral squamous cell carcinomas.Oncotarget · 2017Article
- Transforming growth factor-β1 activates ΔNp63/c-Myc to promote oral squamous cell carcinoma.Oral surgery, oral medicine, oral pathology and oral radiology · 2016Article
- Article
- High RAB25 expression is associated with good clinical outcome in patients with locally advanced head and neck squamous cell carcinoma.Cancer medicine · 2013Article
- Genome stability pathways in head and neck cancers.International journal of genomics · 2013Review
- Deficient DNA damage signaling leads to chemoresistance to cisplatin in oral cancer.Molecular cancer therapeutics · 2012Article
- Monoclonal antibodies against Xenopus greatwall kinase.Hybridoma (2005) · 2011Article
- More forks on the road to replication stress recovery.Journal of molecular cell biology · 2011Review
- The role of RPA2 phosphorylation in homologous recombination in response to replication arrest.Carcinogenesis · 2010Article
- Replication protein A: directing traffic at the intersection of replication and repair.Frontiers in bioscience (Landmark edition) · 2010Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundResistance to chemotherapy is a major limitation in the treatment of head and neck squamous cell carcinomas (HNSCCs), accounting for high mortality rates in patients. Here, we investigated the role of replication protein A (RPA) in cisplatin and etoposide resistance.
methodsWe used 6 parental HNSCC cell lines. We also generated 1 cisplatin-resistant progeny subline from a parental cisplatin-sensitive cell line, to examine cisplatin resistance and sensitivity with respect to RPA2 hyperphosphorylation and cell-cycle response.
resultsCisplatin-resistant HNSCC cell levels of hyperphosphorylated RPA2 in response to cisplatin were 80% to 90% greater compared with cisplatin-sensitive cell lines. RPA2 hyperphosphorylation could be induced in the cisplatin-resistant HNSCC subline. The absence of RPA2 hyperphosphorylation correlated with a defect in cell-cycle progression and cell survival.
conclusionLoss of RPA2 hyperphosphorylation occurs in HNSCC cells and may be a marker of cellular sensitivities to cisplatin and etoposide in HNSCC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.