ArticleEuropean journal of ophthalmology
Expression of alpha-crystallins in human sebaceous carcinoma of the eyelid.
Article in European journal of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 13 citations in OpenAlex.
- A New Inflammation-Related Risk Model for Predicting Hepatocellular Carcinoma Prognosis.BioMed research international · 2022Article
- The small heat shock protein αA-crystallin negatively regulates pancreatic tumorigenesis.Oncotarget · 2016Article
- HspB1, HspB5 and HspB4 in Human Cancers: Potent Oncogenic Role of Some of Their Client Proteins.Cancers · 2014Article
- Downregulation of AlphaB-crystallin in Retinal Pigment Epithelial Cells Exposed to Diabetes-related StimuliIn vivo (Athens, Greece)Article
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Authors and funding
3 authors at 2 institutions in 1 country.
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Abstract
purposeCrystallins are molecular chaperones that protect various cells from apoptosis. This study used immunohistochemistry to examine the expression of alphaA-crystallin and alphaB-crystallin in human sebaceous carcinoma tissues.
methodsNine patients with sebaceous carcinoma of the eyelid underwent excision of the eyelid or orbital exenteration. Formalin-fixed, paraffin-embedded tissue sections were submitted for hematoxylin-eosin staining and immunohistochemistry with anti-alphaA- and alphaB-crystallin antibodies.
resultsIn the noncancerous eyelid, crystallins were weakly and homogeneously expressed in the Meibomian gland lobules. In eyelids with sebaceous carcinoma, alphaA-crystallin and alphaB-crystallin were highly expressed in 4 cases, where the cytoplasmic immunoreactivity was heterogeneously detected in the tumor cells. Three and 2 cases were shown to express low levels of alphaA-crystallin and alphaB-crystallin, respectively. A statistically significant correlation was observed between expression levels of alphaA-crystallin and alphaB-crystallin in sebaceous carcinomas (p=0.012). All sebaceous carcinoma tissues contained mitotic tumor cells, which showed predominantly perinuclear immunoreactivity of alphaB-crystallin. The mitotic rate of tumor cells was 5.85+/-1.76 and 10.72+/-1.64 in high and moderate/low alphaB-crystallin-expressing cases, respectively. The number of mitotic cells was significantly higher in moderate/low alphaB-crystallin-positive than in high-positive cases (p<0.01).
conclusionsCrystallins are expressed in human sebaceous carcinomas including mitotic cells. Expression of alphaB-crystallin correlated with low number of mitotic tumor cells, suggesting that alphaB-crystallin may play a potential role in the regulation of tumor cell proliferation.
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