ArticleMolecular and cellular biochemistry2010
Homocysteine modulates the proteolytic potential of human arterial smooth muscle cells through a reactive oxygen species dependant mechanism.
Article in Molecular and cellular biochemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Pooled it
- Article
- A Narrative Review of Biomarkers and Imaging in the Diagnosis of Acute Aortic Syndrome.Diagnostics (Basel, Switzerland) · 2025Review
- Hyperhomocysteinemia and intracranial aneurysm: A mendelian randomization study.Frontiers in neurology · 2022Article
- The association between homocysteine levels and cardiovascular disease risk among middle-aged and elderly adults in Taiwan.BMC cardiovascular disorders · 2021Article
- Review
- Early Programming of Adult Systemic Essential Hypertension.International journal of molecular sciences · 2020Review
- Hydrogen sulphide mitigates homocysteine-induced apoptosis and matrix remodelling in mesangial cells through Akt/FOXO1 signalling cascade.Cellular signalling · 2019Article
- Hyperhomocysteinaemia and vascular injury: advances in mechanisms and drug targets.British journal of pharmacology · 2018Review
- Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury.Nature communications · 2018Article
- Homocysteine-Enhanced Proteolytic and Fibrinolytic Processes in Thin Intraluminal Thrombus and Adjacent Wall of Abdominal Aortic Aneurysm: Study In Vitro.BioMed research international · 2018Article
- No Association between Elevated Total Homocysteine Levels and Functional Outcome in Elderly Patients with Acute Cerebral Infarction.Frontiers in aging neuroscience · 2017Article
- Arterial stiffness is not associated with bone parameters in an elderly hyperhomocysteinemic population.Journal of bone and mineral metabolism · 2016Article
- Atypical glomerulopathy associated with the cblE inborn error of vitamin B₁₂ metabolism.Pediatric nephrology (Berlin, Germany) · 2013Article
- Matrix metalloproteinases: inflammatory regulators of cell behaviors in vascular formation and remodeling.Mediators of inflammation · 2013Review
- Methionine and homocysteine modulate the rate of ROS generation of isolated mitochondria in vitro.Journal of bioenergetics and biomembranes · 2011Article
- Remodeling in vein expresses arterial phenotype in hyperhomocysteinemia.International journal of physiology, pathophysiology and pharmacology · 2011Article
- Vascular remodeling and arterial calcification are directly mediated by S100A12 (EN-RAGE) in chronic kidney disease.American journal of nephrology · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pathological levels of homocysteine induce a dramatic degradation of arterial elastic structures. This severe metalloproteinase-dependant elastolysis affects elastic structures all over the media suggesting that smooth muscle cells (SMC) may participate to this process induced by homocysteine. Therefore, we investigated the effect of physiological (10 microM) and pathological (50, 100, and 500 microM) concentrations of homocysteine on the metalloproteinase-dependant proteolytic potential of human arterial SMC in culture. Pathological levels of homocysteine increased concomitantly the secretion of latent MMP-2 and TIMP-2 while the secretion of other elastolytic matrix metalloproteinases (MMPs) and expression of MT1-MMP were not altered. The increased secretion of latent MMP-2 induced by homocysteine was associated with an increased production of reactive oxygen species (ROS). Moreover, the increased secretion of latent MMP-2 induced by homocysteine was inhibited by antioxidant superoxide dismutase alone or in combination with catalase. These results suggest that SMC could participate, through an oxidative stress dependant secretion of elastolytic MMP-2, to the metalloproteinase-dependant degradation of arterial elastic structures induced by homocysteine.
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Registered trials
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