ReviewNature reviews. Rheumatology2009
New methods to diagnose and treat cartilage degeneration.
Review in Nature reviews. Rheumatology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- An Ultrasound-Responsive Bio-Adhesive Piezoelectric Hydrogel for Osteoarthritis Cartilage.Gels (Basel, Switzerland) · 2026Article
- Quantitative ultrasound classification of healthy and chemically degraded ex-vivo cartilage.Scientific reports · 2025Article
- Insights into bone and cartilage responses to pulsed electromagnetic field stimulation: a review with quantitative comparisons.Frontiers in bioengineering and biotechnology · 2025Review
- Multidisciplinary Rehabilitation after Hyaluronic Acid Injections for Elderly with Knee, Hip, Shoulder, and Temporomandibular Joint Osteoarthritis.Medicina (Kaunas, Lithuania) · 2023Review
- Electrically Conductive Hydrogels for Articular Cartilage Tissue Engineering.Gels (Basel, Switzerland) · 2022Review
- Chondroinductive/chondroconductive peptides and their-functionalized biomaterials for cartilage tissue engineering.Bioactive materials · 2022Review
- Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications-A Review.Polymers · 2020Review
- A Novel Strategy to Enhance Microfracture Treatment With Stromal Cell-Derived Factor-1 in a Rat Model.Frontiers in cell and developmental biology · 2020Article
- Atsttrin Promotes Cartilage Repair Primarily Through TNFR2-Akt Pathway.Frontiers in cell and developmental biology · 2020Article
- From skeletal development to the creation of pluripotent stem cell-derived bone-forming progenitors.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Polymers in Cartilage Defect Repair of the Knee: Current Status and Future Prospects.Polymers · 2016Review
- Current research on pharmacologic and regenerative therapies for osteoarthritis.Bone research · 2016Review
- The current state of scaffolds for musculoskeletal regenerative applications.Nature reviews. Rheumatology · 2015Review
- Nanocomposite scaffold for chondrocyte growth and cartilage tissue engineering: effects of carbon nanotube surface functionalization.Tissue engineering. Part A · 2014Article
- Heading toward a modern imaging approach in juvenile idiopathic arthritis.Current rheumatology reports · 2014Review
- Current perspectives in stem cell research for knee cartilage repair.Stem cells and cloning : advances and applications · 2014Review
- Articular Cartilage Repair: Where We Have Been, Where We Are Now, and Where We Are Headed.Cartilage · 2013Article
- Anisotropic fibrous scaffolds for articular cartilage regeneration.Tissue engineering. Part A · 2012Article
- Regenerative medicine in rheumatic disease-progress in tissue engineering.Nature reviews. Rheumatology · 2012Review
- Surgical treatment for early osteoarthritis. Part I: cartilage repair procedures.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lesions in articular cartilage can result in significant musculoskeletal morbidity and display unique biomechanical characteristics that make repair difficult, at best. Several surgical procedures have been devised in an attempt to relieve pain, restore function, and delay or stop the progression of cartilaginous lesions. Advanced MRI and ultrasonography protocols are currently used in the evaluation of tissue repair and to improve diagnostic capability. Other nonoperative modalities, such as injection of intra-articular hyaluronic acid or supplementary oral glucosamine and chondroitin sulfate, have shown potential efficacy as anti-inflammatory and symptom-modifying agents. The emerging field of tissue engineering, involving the use of a biocompatible, structurally and mechanically stable scaffold, has shown promising early results in cartilage tissue repair. Scaffolds incorporating specific cell sources and bioactive molecules have been the focus in this new exciting field. Further work is required to better understand the behavior of chondrocytes and the variables that influence their ability to heal articular lesions. The future of cartilage repair will probably involve a combination of treatments in an attempt to achieve a regenerative tissue that is both biomechanically stable and, ideally, identical to the surrounding native tissues.
Indexed as
Identifiers
19786989What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.