Evidence map›Paper›PMID 19786641›Full record

ReviewCirculation2009

Molecular insights and therapeutic targets for diabetic endothelial dysfunction.

Jian Xu, Ming-Hui Zou

Registry-linked trialAbstract readReview
In one paragraph

Review in Circulation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04885153 (Effects of Oral Fenofibrate on Retinal Thickness and Macular Volume), which is not on this map. Cited by 174 papers.

0numbers the graph read from it
0cells of the map it votes in
174citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04885153 nacompletednot on this mapstarted 2016, after this paper: background citation

Effects of Oral Fenofibrate on Retinal Thickness and Macular Volume: Assessments on Retinal Endothelial Vascular Dysfunction, Inflammation, and Angiogenesis in Diabetic Retinopathy With Dyslipidemia

TypeinterventionalSponsorIndonesia UniversityRan2016 to 2017Enrolled36ConditionsDiabetic Retinopathy, Dyslipidemias, Diabetes MellitusArmsFenofibrate, Placebo
3 · Its place in the literature

Who cites it

174 citing papers in PubMed.

  1. Trial
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  10. Endothelial Metabolic Reprogramming Links Diabetes to Atherosclerosis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026
    Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Nutrients · 2025
    Review
  17. Article
  18. Regeneration of Vascular Endothelium in Different Large Vessels.International journal of molecular sciences · 2025
    Review
  19. Review
  20. Review

114 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jian XuDepartment of Medicine and Endocrinology, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.
Ming-Hui Zou

Funding

Reactive Nitrogen species and Diabetic Endothelial DysfunctionR01HL079584 · NHLBI · UNIVERSITY OF TENNESSEE KNOXVILLE · PI ZOU, MING-HUI · 2004 to 2021
$7.3M
Inflammasome and unstable atherosclerotic plaquesR01HL089920 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZOU, MING-HUI · 2008 to 2022
$6.9M
AMP-Activated Protein Kinase in DiabetesR01HL080499 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZOU, MING-HUI · 2006 to 2019
$5.8M
Controlling VSMC Proliferation and MigrationR01HL110488 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZOU, MING-HUI · 2011 to 2020
$3.9M
Oxidant stress and diabetic endothelial dysfunctionR01HL074399 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZOU, MING-HUI · 2005 to 2013
$3.2M
Prevention of High Fat Diet-Induced Vascular InjuryR01HL105157 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZOU, MING-HUI · 2010 to 2014
$1.8M
Angiotensin-II, GTPCH1 and 26S ProtesomesR01HL096032 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZOU, MING-HUI · 2009 to 2013
$1.8M
NHLBI NIH HHS HL074399NHLBI NIH HHS HL079584NHLBI NIH HHS HL080499NHLBI NIH HHS HL089920NHLBI NIH HHS HL096032NHLBI NIH HHS R01 HL074399NHLBI NIH HHS R01 HL079584NHLBI NIH HHS R01 HL080499NHLBI NIH HHS R01 HL089920NHLBI NIH HHS R01 HL096032NHLBI NIH HHS R01 HL105157NHLBI NIH HHS R01 HL110488
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsCardiovascular DiseasesDiabetic AngiopathiesEndothelium, VascularHumans

Identifiers

PMID19786641
PMCPMC2910587

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.