ArticleGenetics2009
Mapping loci associated with tail color and sex determination in the short-lived fish Nothobranchius furzeri.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Strategies for studying sex differences in brain aging.Trends in genetics : TIG · 2025Review
- The genome of the MZM-0403 strain of the African turquoise killifish, Nothobranchius furzeri.G3 (Bethesda, Md.) · 2025Article
- The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization.Nature communications · 2025Article
- A short-lived fish with long-lasting effects: hallmarks of aging inFrontiers in aging · 2025Review
- The African Turquoise Killifish: A Scalable Vertebrate Model for Aging and Other Complex Phenotypes.Cold Spring Harbor protocols · 2024Article
- Article
- Zebrafish, Medaka and Turquoise Killifish for Understanding Human Neurodegenerative/Neurodevelopmental Disorders.International journal of molecular sciences · 2022Review
- The Utility of Small Fishes for the Genetic Study of Human Age-Related Disorders.Frontiers in genetics · 2022Article
- Variation in developmental rates is not linked to environmental unpredictability in annual killifishes.Ecology and evolution · 2021Article
- Alternative Animal Models of Aging Research.Frontiers in molecular biosciences · 2021Review
- Article
- Article
- Review
- The African turquoise killifish: A research organism to study vertebrate aging and diapause.Aging cell · 2018Review
- A Protocol for Laboratory Housing of Turquoise Killifish (Nothobranchius furzeri).Journal of visualized experiments : JoVE · 2018Article
- Longitudinal demographic study of wild populations of African annual killifish.Scientific reports · 2018Article
- Non-model model organisms.BMC biology · 2017Article
- Efficient genome engineering approaches for the short-lived African turquoise killifish.Nature protocols · 2016Article
- The short-lived African turquoise killifish: an emerging experimental model for ageing.Disease models & mechanisms · 2016Review
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The African fish Nothobranchius furzeri is the shortest-lived vertebrate species that can reproduce in captivity, with a median life span of 9-11 weeks for the shortest-lived strain. Natural populations of N. furzeri display differences in life span, aging biomarkers, behavior, and color, which make N. furzeri a unique vertebrate system for studying the genetic basis of these traits. We mapped regions of the genome involved in sex determination and tail color by genotyping microsatellite markers in the F(2) progeny of a cross between a short-lived, yellow-tailed strain and a long-lived, red-tailed strain of N. furzeri. We identified one region linked with the yellow/red tail color that maps close to melanocortin 1 receptor (mc1r), a gene involved in pigmentation in several vertebrate species. Analysis of the segregation of sex-linked markers revealed that N. furzeri has a genetic sex determination system with males as the heterogametic sex and markedly reduced recombination in the male sex-determining region. Our results demonstrate that both naturally-evolved pigmentation differences and sex determination in N. furzeri are controlled by simple genetic mechanisms and set the stage for the molecular genetic dissection of factors underlying such traits. The microsatellite-based linkage map we developed for N. furzeri will also facilitate analysis of the genetic architecture of traits that characterize this group of vertebrates, including short life span and adaptation to extreme environmental conditions.
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