ArticleAntimicrobial agents and chemotherapy2009
Modifying culture conditions in chemical library screening identifies alternative inhibitors of mycobacteria.
Article in Antimicrobial agents and chemotherapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- High-Throughput Screening of Natural Product and Synthetic Molecule Libraries for Antibacterial Drug Discovery.Metabolites · 2023Review
- An Oral Fluorouracil Prodrug, Capecitabine, Mitigates a Gram-Positive Systemic Infection in Mice.Microbiology spectrum · 2021Article
- Inhibition of Indigoidine Synthesis as a High-Throughput Colourimetric Screen for Antibiotics Targeting the EssentialPharmaceutics · 2021Article
- A systems approach to infectious disease.Nature reviews. Genetics · 2020Review
- Microtiter Screening Reveals Oxygen-Dependent Antimicrobial Activity of Natural Products Against Mastitis-Causing Bacteria.Frontiers in microbiology · 2019Article
- Oxadiazoles Have Butyrate-Specific Conditional Activity against Mycobacterium tuberculosis.Antimicrobial agents and chemotherapy · 2016Article
- Detection of inhibitors of phenotypically drug-tolerant Mycobacterium tuberculosis using an in vitro bactericidal screen.Journal of microbiology (Seoul, Korea) · 2013Article
- Targeting the chromosome partitioning protein ParA in tuberculosis drug discovery.The Journal of antimicrobial chemotherapy · 2010Article
- Native New Zealand plants with inhibitory activity towards Mycobacterium tuberculosis.BMC complementary and alternative medicine · 2010Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
In this study, application of a dual absorbance/fluorescence assay to a chemical library screen identified several previously unknown inhibitors of mycobacteria. In addition, growth conditions had a significant effect on the activity profile of the library. Some inhibitors such as Se-methylselenocysteine were detected only when screening was performed under nutrient-limited culture conditions as opposed to nutrient-rich culture conditions. We propose that multiple culture condition library screening is required for complete inhibitory profiling and for maximal antimycobacterial compound detection.
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