ArticleAntimicrobial agents and chemotherapy2009
Paradoxical growth of Candida dubliniensis does not preclude in vivo response to echinocandin therapy.
Article in Antimicrobial agents and chemotherapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Deciphering Candida auris Paradoxical Growth Effect (Eagle Effect) in Response to Echinocandins.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Minimal Inhibitory Concentration (MIC)-Phenomena inJournal of fungi (Basel, Switzerland) · 2019Article
- Understanding Echinocandin Resistance in the Emerging Pathogen Candida auris.Antimicrobial agents and chemotherapy · 2018Article
- Recent Insights into the Paradoxical Effect of Echinocandins.Journal of fungi (Basel, Switzerland) · 2017Review
- Usefulness of the Non-conventional Caenorhabditis elegans Model to Assess Candida Virulence.Mycopathologia · 2017Article
- Characterization of In Vitro Resistance Development to the Novel Echinocandin CD101 in Candida Species.Antimicrobial agents and chemotherapy · 2016Article
- In vitro fungicidal activities of anidulafungin, caspofungin, and micafungin against Candida glabrata, Candida bracarensis, and Candida nivariensis evaluated by time-kill studies.Antimicrobial agents and chemotherapy · 2015Article
- Paradoxical growth of Candida albicans in the presence of caspofungin is associated with multiple cell wall rearrangements and decreased virulence.Antimicrobial agents and chemotherapy · 2014Article
- Paradoxical effect of caspofungin against Candida bloodstream isolates is mediated by multiple pathways but eliminated in human serum.Antimicrobial agents and chemotherapy · 2011Article
- Changes in cell wall synthesis and ultrastructure during paradoxical growth effect of caspofungin on four different Candida species.Antimicrobial agents and chemotherapy · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Candida dubliniensis commonly shows paradoxical or trailing growth effects in vitro in the presence of echinocandins. We tested the in vitro activities of anidulafungin, caspofungin, and micafungin against clinical isolates of C. dubliniensis and evaluated the efficacy of these drugs in two murine models of systemic infection. The three echinocandins were similarly effective in the treatment of experimental disseminated infections with C. dubliniensis strains showing or not showing abnormal growth in vitro.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.