ArticleAntimicrobial agents and chemotherapy2009
Spread of bla(CTX-M-14) is driven mainly by IncK plasmids disseminated among Escherichia coli phylogroups A, B1, and D in Spain.
Article in Antimicrobial agents and chemotherapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed.
- Article
- Interplay between bacterial clones and plasmids in the spread ofOne health (Amsterdam, Netherlands) · 2025Article
- Stool carriage of CTX-M/CMY-producingFrontiers in cellular and infection microbiology · 2025Article
- Plasmid-mediated acquisition and chromosomal integration ofAntimicrobial agents and chemotherapy · 2024Article
- Prevalence of CTX-M types among ESBL-producing pathogenicFood science and biotechnology · 2024Article
- Natural products from food sources can alter the spread of antimicrobial resistance plasmids inMicrobiology (Reading, England) · 2024Article
- Multidrug resistance plasmids commonly reprogram the expression of metabolic genes inmSystems · 2024Article
- ESBL/Antibiotics (Basel, Switzerland) · 2022Article
- Antimicrobial Resistance inAntibiotics (Basel, Switzerland) · 2022Article
- Genomic Characterization of ESBL/AmpC-ProducingInfection and drug resistance · 2022Article
- Emergence and Spread of Cephalosporinases in Wildlife: A Review.Animals : an open access journal from MDPI · 2021Review
- Approaches for characterizing and tracking hospital-associated multidrug-resistant bacteria.Cellular and molecular life sciences : CMLS · 2021Review
- High Prevalence and Diversity of Cephalosporin-ResistantAntibiotics (Basel, Switzerland) · 2020Article
- Article
- Multiple NDM-5-ExpressingOpen forum infectious diseases · 2020Article
- Influence of the α-Methoxy Group on the Reaction of Temocillin with Pseudomonas aeruginosa PBP3 and CTX-M-14 β-Lactamase.Antimicrobial agents and chemotherapy · 2019Article
- Article
- Translating antibiotic prescribing into antibiotic resistance in the environment: A hazard characterisation case study.PloS one · 2019Article
- Characterization and Bio-Typing of Multidrug Resistance Plasmids From UropathogenicFrontiers in microbiology · 2019Article
- CTX-M ESBL-producing Enterobacteriaceae: estimated prevalence in adults in England in 2014.The Journal of antimicrobial chemotherapy · 2018Article
3 more citing papers are in PubMed but not listed here.
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9 authors.
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Abstract
Since its first description in 2000, CTX-M-14 has become one of the most widespread extended-spectrum beta-lactamases in Spain. In the present Escherichia coli multilevel population genetic study involving the characterization of phylogroups, clones, plasmids, and genetic platforms, 61 isolates from 16 hospitalized patients and 40 outpatients and healthy volunteers recovered from 2000 to 2005 were analyzed. Clonal relatedness (XbaI pulsed-field gel electrophoresis [PFGE] type, phylogenetic group, multilocus sequence type [MLST]) was established by standard methods. Analysis of transferred plasmids (I-CeuI; S1 nuclease; restriction fragment length polymorphism analysis; and analysis of RNA interference, replicase, and relaxase) was performed by PCR, sequencing, and hybridization. The genetic environment of bla(CTX-M-14) was characterized by PCR on the basis of known associated structures (ISEcp1, IS903, ISCR1). The isolates were mainly recovered from patients in the community (73.8%; 45/61) with urinary tract infections (62.2%; 28/45). They were clonally unrelated by PFGE and corresponded to phylogenetic groups A (36.1%), D (34.4%), and B1 (29.5%). MLST revealed a high degree of sequence type (ST) diversity among phylogroup D isolates and the overrepresentation of the ST10 complex among phylogroup A isolates and ST359/ST155 among phylogroup B1 isolates. Two variants of bla(CTX-M-14) previously designated bla(CTX-M-14a) (n = 59/61) and bla(CTX-M-14b) (n = 2/61) were detected. bla(CTX-M-14a) was associated with either ISEcp1 within IncK plasmids (n = 27), ISCR1 linked to an IncHI2 plasmid (n = 1), or ISCR1 linked to IncI-like plasmids (n = 3). The bla(CTX-M-14b) identified was associated with an ISCR1 element located in an IncHI2 plasmid (n = 1) or with ISEcp1 located in IncK (n = 1). The CTX-M-14-producing E. coli isolates in our geographic area are frequent causes of community-acquired urinary tract infections. The increase in the incidence of such isolates is mostly due to the dissemination of IncK plasmids among E. coli isolates of phylogroups A, B1, and D.
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