ArticleInfection and immunity2009
Coxiella burnetii isolates cause genogroup-specific virulence in mouse and guinea pig models of acute Q fever.
Article in Infection and immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
63 citing papers in PubMed, 105 citations in OpenAlex.
- Genome characteristics and type IV effector protein repertoire of Coxiella burnetii depend rather on Genomic Groups than on host species.BMC microbiology · 2026Article
- Control of human Q fever by vaccination: the journey to Q-VAX and beyond.Infection and immunity · 2025Review
- The first serological survey of C. Burnetii in domestic animals in Poland.BMC veterinary research · 2024Article
- Synthetic Particulate Subunit Vaccines for the Prevention of Q Fever.Advanced healthcare materials · 2024Article
- Vaccine development: obligate intracellular bacteria new tools, old pathogens: the current state of vaccines against obligate intracellular bacteria.Frontiers in cellular and infection microbiology · 2024Review
- Identification of essential genes inMicrobial genomics · 2023Article
- Infection and Persistence ofInternational journal of molecular sciences · 2023Article
- Genomic detection ofVeterinary research forum : an international quarterly journal · 2023Article
- Phenotype ofPathogens (Basel, Switzerland) · 2022Article
- Characterization ofMicroorganisms · 2022Article
- Review
- Molecular diagnosis ofAnnals of medicine · 2021Article
- Article
- Q Fever Vaccine Development: Current Strategies and Future Considerations.Pathogens (Basel, Switzerland) · 2021Review
- Q Fever: A troubling disease and a challenging diagnosis.Clinical microbiology newsletter · 2021Article
- Conditional impairment of Coxiella burnetii by glucose-6P dehydrogenase activity.Pathogens and disease · 2021Article
- FromPathogens (Basel, Switzerland) · 2021Review
- Correlating Genotyping Data ofPathogens (Basel, Switzerland) · 2021Article
- TheJournal of bacteriology · 2021Article
- Contributions of lipopolysaccharide and the type IVB secretion system to Coxiella burnetii vaccine efficacy and reactogenicity.NPJ vaccines · 2021Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 3 countries.
Funding
Abstract
Q fever is a zoonotic disease of worldwide significance caused by the obligate intracellular bacterium Coxiella burnetii. Humans with Q fever may experience an acute flu-like illness and pneumonia and/or chronic hepatitis or endocarditis. Various markers demonstrate significant phylogenetic separation between and clustering among isolates from acute and chronic human disease. The clinical and pathological responses to infection with phase I C. burnetii isolates from the following four genomic groups were evaluated in immunocompetent and immunocompromised mice and in guinea pig infection models: group I (Nine Mile, African, and Ohio), group IV (Priscilla and P), group V (G and S), and group VI (Dugway). Isolates from all of the groups produced disease in the SCID mouse model, and genogroup-consistent trends were noted in cytokine production in response to infection in the immunocompetent-mouse model. Guinea pigs developed severe acute disease when aerosol challenged with group I isolates, mild to moderate acute disease in response to group V isolates, and no acute disease when infected with group IV and VI isolates. C. burnetii isolates have a range of disease potentials; isolates within the same genomic group cause similar pathological responses, and there is a clear distinction in strain virulence between these genomic groups.
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Registered trials
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