Evidence map›Paper›PMID 19786427›Full record

Trial reportPediatrics2009

Prediction of birth weight by cotinine levels during pregnancy in a population of black smokers.

Ayman A E El-Mohandes, Michele Kiely, Marie G Gantz, Susan M Blake, M Nabil El-Khorazaty

Abstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pediatrics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

  1. Impact of smoking exposure change on infant birth weight among a cohort of women in a prenatal smoking cessation study.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2013
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Ayman A E El-MohandesDepartment of Prevention and Community Health, School of Public Health and Health Services, George Washington University Medical Center, 2175 K St NW, Suite 700, Washington, DC 20037, USA. sphaxe@gwumc.edu
Michele Kiely
Marie G Gantz
Susan M Blake
M Nabil El-Khorazaty
George Washington University · USRTI International · USEunice Kennedy Shriver National Institute of Child Health and Human Development · US

Funding

NIH DC INITIATIVE TO REDUCE INFANT MORTALITYU18HD031206 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI EL-KHORAZATY, NABIL · 1993 to 2003
$6.0M
NIH D.C. INITIATIVE TO REDUCE INFANT MORTALITYU18HD031919 · NICHD · HOWARD UNIVERSITY · PI JOHNSON, ALLAN ALEXANDER · 1993 to 2003
$3.8M
COOPERATIVE PERINATAL STUDIES AND INTERVENTIONSU18HD030445 · NICHD · GEORGETOWN UNIVERSITY · PI SIVASUBRAMANIAN, KOLINJAVADI N · 1992 to 2003
$3.7M
NIH D.C. INITIATIVE TO REDUCE INFANT MORTALITYU18HD036104 · NICHD · GEORGE WASHINGTON UNIVERSITY · PI EL-MOHANDES, AYMAN A · 1998 to 2003
$2.7M
COOPERATIVE PERINATAL STUDIES AND INTERVENTIONSU18HD030447 · NICHD · CHILDREN'S NATIONAL MEDICAL CENTER · PI JOSEPH, JILL G. · 1992 to 2003
$1.7M
Intramural NIH HHS Z99 HD999999NICHD NIH HHS 3U18HD030447NICHD NIH HHS 3U18HD03919NICHD NIH HHS 5U18HD036104NICHD NIH HHS 5U18HD31206NICHD NIH HHS U18 HD030445NICHD NIH HHS U18HD030445NICHD NIH HHS U18 HD030447NICHD NIH HHS U18 HD031206NICHD NIH HHS U18 HD031919NICHD NIH HHS U18 HD036104
6 · The paper itself

Abstract

objectiveThe goal was to investigate the association between maternal salivary cotinine levels (SCLs) and pregnancy outcomes among black smokers.

methodsIn a randomized, controlled trial conducted in 2001-2004 in Washington, DC, 714 women (126 active smokers [18%]) were tested for SCLs at the time of recruitment and later in pregnancy. Sociodemographic health risks and pregnancy outcomes were recorded.

resultsBirth weights were significantly lower for infants born to mothers with baseline SCLs of > or =20 ng/mL in comparison with <20 ng/mL (P = .024), > or =50 ng/mL in comparison with <50 ng/mL (P = .002), and > or =100 ng/mL in comparison with <100 ng/mL (P = .002), in bivariate analyses. In linear regression analyses adjusting for sociodemographic and medical factors, SCLs of > or =20 ng/mL were associated with a reduction in birth weight of 88 g when SCLs were measured at baseline (P = .042) and 205 g when SCLs were measured immediately before delivery (P < .001). Corresponding results were 129 g (P = .006) and 202 g (P < .001) for > or =50 ng/mL and 139 g (P = .007) and 205 g (P < .001) for > or =100 ng/mL. Gestational age was not affected significantly at any SCL, regardless of when SCLs were measured.

conclusionsElevated SCLs early in pregnancy or before delivery were associated with reductions in birth weight. At any cutoff level, birth weight reduction was more significant for the same SCL measured in late pregnancy. Maintaining lower levels of smoking for women who are unable to quit may be beneficial.

Indexed as

Birth WeightAttitude to HealthBiomarkersBlack or African AmericanCotinineFemaleGestational AgeHumansInfant, NewbornInfant, Small for Gestational AgeMaleMaternal ExposurePredictive Value of TestsPregnancyPregnancy ComplicationsPregnancy OutcomeBiomarkersCotinine

Identifiers

PMID19786427
PMCPMC2922025
OpenAlexW2153673370

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.